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This study tells us how a 'good guy' protein in the body called PINK1 gets powered up at a special assembly point named TOM to keep our cells healthy. All this was figured out using a lab-made system.

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system biorxiv.org/content/10.110…

Out Now! Our new preprint of mechanism of #PINK1 activation at TOM complex. Led by Wale OLAWALE RAIMI & Hina MRC PPU Fantastic collaboration with Ruben Fernandez Sebastian Mathea Aligning Science Across Parkinson’s Karim Labib Neil Ranson Tom Deegan. #OpenScience click here surl.li/oqvpt

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Mechanism of human PINK1 activation at the TOM complex in a reconstituted system | Science Advances science.org/doi/10.1126/sc…

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Out Now! New collaborative Aligning Science Across Parkinson’s study with Dario Alessi MRC PPU and Suzanne Pfeffer. Deep analysis of #LRRK2 and #PINK1 reveals convergent #ciliogenesis defect in brain striatum. Implications for #Parkinson therapies Click here for preprint shorturl.at/Fx9aK

Wale and Hina reveal mechanism of #PINK1 activation at the TOM complex ppu.mrc.ac.uk/news/wale-and-… Miratul Muqit #Parkinsons

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Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with Ganley Lab Rousseau Lab MRC PPU & @GlennMasson Click here for paper shorturl.at/G0IzL

Fantastic to have led this interesting work on the regulation of PINK by ISR with Pawan, IlariaVolpi Miratul Muqit and see this online. Great teamwork and collaborators Léa Wilhelm Ganley Lab @GlennMasson Rousseau Lab MRC PPU. Please check it out!

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling biorxiv.org/content/10.110…

Researchers leading groundbreaking cancer and Parkinson’s research have been given almost £30 million to bolster their vital work over the next five years. 👏 We are enormously grateful to Medical Research Council – UKRI for their generous support for MRC PPU. More: buff.ly/3XbPTuA

Department chair search