"Antibiotics are the cornerstone of medicine." "That cornerstone is about to crumble."

"Multidrug-resistance is bad, but once a pathogen gains resistance to all known antibiotics, known as pan-resistance, a dramatically rapid shift, rather than a gradual rise in public health impacts, can be expected" medicalxpress.com/news/2024-12-h…

"[R]esearchers modeled the impact of one hypothetical pan-resistant strain of E. coli on sepsis deaths in the US...The models...showed that sepsis deaths could increase by 18 to 46 times just five years after the introduction of such a strain."

"Recently…WHO endorsed new regimens for the treatment of MDR-TB that rely on…bedaquiline, pretomanid, and linezolid with…moxifloxacin [BPaL/M]…Despite the recent introduction of BPaL/M, resistance has…developed in…27 countries across 4 continents." nejm.org/doi/10.1056/NE…

'[W]e identified 9 highly drug-resistant strains from 4 countries that carried resistance mutations to [rifampin, isoniazide, and] all BPaL/M compounds, thus potentially classifying them as 'totally drug-resistant.'"

"[R]esistance to shorter and less toxic drug regimens for multidrug-resistant tuberculosis (MDR-TB) is emerging and spreading between patients." cidrap.umn.edu/tuberculosis/s…

"The team...found that nine strains carried resistance mutations to [rifampin, isoniazide, fluoroquinolones, and] all of the BPaL/M drugs. These strains, found in four countries—Belarus, Georgia, India, and South Africa—were classified as 'totally drug-resistant.'"

🧵 Biosafety Flashback '09 The University of Texas Medical Branch (UTMB) Commits Perjury while Trying to Shut Down #FOIA on its Bioweapons Agents Research UTMB Health

harish seshadri Hideki Kakeya, Dr.Eng. In the US, research on Ebola virus research is performed in downtown Boston and on the Galveston sandbar (which periodically is scraped to bare sand by hurricanes).

Five years ago today, the emerging pandemic that would go on to kill 20+ million and cost $25+ trillion became unmissable. x.com/R_H_Ebright/st…

Five years ago today, the emerging pandemic that would go on to kill 20+ million and cost $25+ trillion became unmissable. x.com/R_H_Ebright/st…

Five years ago today, the emerging pandemic that would go on to kill 20+ million and cost $25+ trillion became unmissable. x.com/R_H_Ebright/st…

Antibacterial agents: soluble salts and aqueous formulations of pyronins US Patent 12,209,082 (issued 01/28/2025) freepatentsonline.com/12209082.pdf

Biotechs ‘cry for help’ to fix antibiotics market failure Developers are reluctantly shelving promising drugs due to market failure politico.eu/article/biotec…

With a broken market for antibacterial drugs, each ***success*** in developing a new antibacterial drug effective against bacteria resistant to current drugs ***loses*** its developers, and their investors, an average of $50 million.

"Here, we communicate…characterization of MtbRNAP elongation and its inhibition by…N(α)-aroyl-N-aryl-phenylalaninamide…, streptolydigin…, and pseudouridimycin…using…optical tweezers" (Collaboration between our lab and Carlos Bustamante's lab.) biorxiv.org/content/10.110…

"[A]ntimicrobial resistance…is one of the major global threats to human health…[T]he current clinical development pipeline contains little innovation with many analogs of the same known antibiotics or not targeting critical pathogens." revive.gardp.org/how-can-we-clo…

Patent application from Ebright lab at Waksman Institute (03/13/2025).

European patent issued to Ebright lab at Waksman Institute.

Antibacterial agents: soluble salts and aqueous formulations of pyronins US Patent application 20250115594 (filed 04/10/2025) Divisional filing on US Patent 12,209,082 (issued 01/28/2025) freepatentsonline.com/y2025/0115594.…