"Because some evidence indicates that a sustained positive fluid balance during ICU stay is harmful (33–37), fluid administration beyond initial resuscitation requires careful assessment of the likelihood that the patient remains fluid responsive." journals.lww.com/ccmjournal/Ful…

Unintended Consequences; Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia | American Journal of Respiratory and Critical Care Medicine | Articles in Press atsjournals.org/doi/abs/10.116…

Enrolling 1600+ patients into VOLUME-CHASERS #shock study built from #SCCMDiscovery support across 34 sites. MayoPCCM UCLA @UArizonaScience University of Michigan and 30 more! #ATS2019

Important finding from VOLUME-CHASERS is that timing of vasopressor dosing makes a difference: early high/later low has lower mortality than early low/later high #SCCMDiscovery #ATS2019 Ognjen Gajic Jon Sevransky Michelle Ng Gong #sepsis #shock

⁦VOLUME-CHASERS⁩ has so much productive work at ats this year!!@tchen383 ⁦@SlurpeeRx⁩ #ATS2019 ⁦SCCM⁩ #Discovery ⁦Albert Einstein College of Medicine - Official⁩

motivated clinicians committed to icu recovery & #SCCM #THRIVE2019 were important enablers to innovation in this area ⁦CAIRO⁩ #ATS2019

Critical care ultrasound as the most commonly use method of physiologic assessment in shock is still only performed on 31% of the patient in our cohort. (CVP 13%)

Decision for fluid and vasopressor in shock: arbitrary (think aloud study by Dr Aboodi) #myicucrew

Delayed vasopressors in septic shock= higher mortality. Great job dani representing Loyola Medicine at #ATS2019! 🙌@JaiminiP17 @Dalila_Masic

Thank you to all the participating sites! Top 5 enrolling: Mayo, UCLA, UAriazona, Mt Sinai NY, and UMichigan! Kianoush Kashani Nida Qadir, MD Charles Cairns Drs Mathews and Park! and 34 participating sites

1639 patients from 34 sites, in 4 months!!! SCCM ATS Crit Care Michelle Ng Gong Jon Sevransky Joseph Tonna @SlurpeeRx

Food for thought from below: For some interventions, there may be a primary outcome other than mortality (see improveLTO.com) that s/b used-- interesting to think what risk reduction may be possible w/ patient-imp't outcome measures ImproveLTO Victor D. Dinglas, MPH Timothy Girard x.com/icuresearch/st…