Stunning proteomics work on #gastruloids from MVermeulenLab Suz et al. shorturl.at/DKMO6 Transcriptional regulation, degrons, mutants, #mouse and #human, comparison between gastruloids and #embryos. A tour de force. #InNumbersweTrust

Excited to share our paper #BrainTF is published in Nature Neuroscience. We profiled #TF binding using ChIP-seq for over 100 TFs across 9 brain regions, along with ATAC-seq, RNA-seq, and DNA methylation on postmortem human brain tissue. nature.com/articles/s4159… 1/

This is really a 'WOW' paper. 🤯 Claims that MatMul operations can be completely eliminated from LLMs while maintaining strong performance at billion-parameter scales and by utilizing an optimized kernel during inference, their model’s memory consumption can be reduced by more

Wow, @nature has retracted the 2020 Poore et al. cancer microbiome paper that we showed (journals.asm.org/doi/10.1128/mb…) was deeply flawed. The retraction date is tomorrow so I can't yet read the official notice, but I'll update when I can Retraction Watch Professor Booty PhD

New #breakthrough that enables efficient epigenetic editing in the brain with highly reduced toxicity!

A good reminder that publication is the *beginning* of peer review

On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

Great work from Luca Pinello lab on a compact deep learning model that integrates sequence, DNase, H3k27ac (optionally HiC) to predict expression while learning long range effects of enhancers (against CRISPR FlowFISH expts) very well. 1/ biorxiv.org/content/10.110…

Excited to share our human RA-gastruloid model in Nature Cell Biology! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in

Interested in navigating #metabolism in space and time? Meet uMAIA (the Unified Mass Imaging Analyzer) - a framework developed in collaboration with Giovanni D'Angelo & oaties EPFL Life Sciences led by Halima Hannah Schede & Leila #omics #lipidtime #MALDI biorxiv.org/content/10.110… 1/N

Researchers should stop paying to publish their papers. Tom Morgan and I wrote a short piece about it. 1/3 osf.io/preprints/osf/…

“towards a single cell atlas of” has been replaced by “towards a foundation model of”

Thanks to Cell for highlighting our journey with Turvey lab and how #science is about NOT boxing ourselves in to different categories! Humans are unreliable models of mouse disease sciencedirect.com/science/articl…

Terence Tao’s grading: GPT-4o: Completely incompetent graduate student o1-preview: Mediocre but not completely incompetent graduate student A step change.

STAMP is OUT! Sequencing-free #singlecell RNA and Protein profiling. Game-changing approach for scalable and cost-efficient analysis of single cells. The future starts today! Amazing ⁦Luciano Martelotto 🛠🧬💻🇦🇺⁩ ⁦Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸⁩ biorxiv.org/content/10.110…

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9