Vish Chandrasekaran
@vishy_chandra
Senior Investigator Scientist @MRC_LMB
Structural Biologist
ID: 1256250594152583168
01-05-2020 15:54:45
315 Tweet
450 Followers
427 Following
Wonderful collaboration with Aleksandra Filipovska reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. Science Magazine science.org/doi/10.1126/sc…
We (with Kiarash Jamali and Dari Kimanius) present #ModelAngelo version 1.0 for automated model building of proteins and nucleotides, as well as protein identification in #cryoEM maps. A #tweetorial below. biorxiv.org/content/10.110…
🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with Eva Absmeier, Lori Passmore & Ivana Gasic 🧵 1/ cell.com/molecular-cell…
Excited to share our latest work on bioRxiv! We visualised single molecules of dynein and its cofactors live in the axon. Work by Alex Fellows in collaboration with the Wellcome Sanger Institute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold) biorxiv.org/content/10.110…
Exciting #postdoc opportunity with Lori Passmore to study transcription and mRNA processing using cryo-electron tomography and single particle cryoEM: nature.com/naturecareers/… Deadline: 15 SEP #PostdocJobs #ScienceJobs Please RT!
Here's a NSMB Research Briefing summarising this work, with Lori Passmore rdcu.be/dlvyE (Also visit Poster 99 tomorrow at the Protein synthesis and translational control EMBL conference #EMBLprotein)
Excited to see fruits of a huge community effort! Thanks to Dr. Tijana Milenkovic for the leadership and the opportunity to be a part of this 🙌🏽
Available now - the Review "#Cotranslational sorting and processing of newly synthesized proteins in eukaryotes" from Martin Gamerdinger and Elke Deuerling Lab. #NacentpolypeptideAssociatedComplex #SignalRecognitionParticle #RibosomeAssociatedComplex authors.elsevier.com/a/1i0Wg_M0e48h…
I am thrilled to share our manuscript published in Nature Reviews Molecular Cell Biology. In this Review (Brito Querido et al., 2023), we discuss the current state of knowledge on eukaryotic translation initiation and its regulation in health and disease.
I am thrilled to share our new paper published in NatureStructMolBiol (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. #Ribosome #mRNA #Science nature.com/articles/s4159…
🥳Thrilled to share our new paper describing Balon, a bacterial ribosome hibernation factor that resembles aeRF1 family proteins. Fantastic collaboration with Karla Helena Bueno Sergey Melnikov and Mariia Rybak 🇺🇦 Matthieu Gagnon nature.com/articles/s4158…
We have optimized a human in-vitro translation system (HITS) for use in #ribosome research Our HITS: 🧪requires a minimal number of components 💵is cheap & easy to prepare 💡enables cap-dependent translation 📈is highly active online now: bit.ly/49xTdVa Cell Reports Methods
The last time MRC Laboratory of Molecular Biology team won the interdepartmental cricket cup John Walker was playing in the side! (1982 we think.) Great game against Chemistry, very close!
The Pitchiaya lab is #hiring! We seek to hire a #Postdoc to work on exciting projects pertaining to stress response mechanisms in cancer - bit.ly/46jzBE8. Email/DM for more info. Michigan Pathology U-M Rogel Cancer Center UMich RNA Center 〽️🧬 Michigan Research Michigan Medicine