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Lipidomics (& #METLIN) reveal a metabolic vulnerability in tumors nature doi.org/10.1038/s41586… Tumors don’t just synthesize their own lipids—they scavenge antioxidant-rich lipoproteins. Javier Garcia-Bermudez w/ our lab's lipidomics uncover how this can be used to impair tumor growth

Beautiful story from Sean on internal electron transfer (ET) in pyruvate:ferredoxin oxidoreductases (PFORs): jbc.org/article/S0021-…

pubs.acs.org/doi/10.1021/ac…

Very proud of the hard work and resilience by Eddie Rashan, Abby Bartlett and many others on this work!

Check out our latest publication: ACLY offloads excess mitochondrial NADH. ACLY-KO results in reductive stress and cardiac damage. Mariam Meddeb Mohammad Keykhaei, MD, MPH Kavita Sharma Virginia Shalkey Hahn, MD Johns Hopkins Cardiology Johns Hopkins Medicine jacc.org/doi/10.1016/j.…

I'm excited to share our new publication in nature! We showed that under Ni-limited conditions, similar to those in nature, #methanogens shift electron flow from [NiFe]- to [Fe]-hydrogenase Hmd with the help of a newly discovered protein complex, Elp. nature.com/articles/s4158…

The company is based on the discovery that the metabolism of stem cells in the hair shaft is critical for the growth phase nature.com/articles/ncb35…

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Focus: Why Every Diabetes Provider Needs to Be a Liver Health Champion in 2025 opmed.doximity.com/articles/metab… via Doximity

A master is gone. I am heartbroken. The X-Files variety.com/2025/tv/news/m…

🕯️ RIP Mark Snow (1946–2025) The truth was out there… but he gave it a sound.He gave The X-Files its haunting soul. For over 30 years, his music was the heartbeat of The X-Files. Your sound will live on.

academic.oup.com/metallomics/ad…

Now >200 papers/preprints on (diseases of) aging/relevant tools citing support from Impetus 📈

Today we say goodbye to Andrew and wish him the best of luck as he starts grad school ⁦NYU Langone Health⁩ !!! ⁦Sarafan ChEM-H⁩ ⁦Stanford Pathology⁩

Hypoxia as a therapy for Parkinson's disease! New study w/ Fumito Ichinose shows PD mice have brain hyperoxia. Chronic 11% FIO2 delays neurodegeneration and *reverses* motor symptoms. Might explain why PD can improve w/altitude (thin air) or smoking (CO). rdcu.be/ezw02

New findings from Vamsi Mootha and @fumitoichinose show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen. broad.io/Parkinsons-Oxy…