We captured the process of a substrate protein through a membrane using HS-AFM. A string-like protein (peptide) is being translocated by a single SecYEG-SecA.
Kanaoka et al., Nature communications (2025)
nature.com/articles/s4146…
Just posted on bioRxiv!
We reveal the structure of the MurJ/LysM (JM) complex.
A small phage protein, LysM (37 residues), binds to MurJ like a wedge and freezes its motion.
biorxiv.org/content/10.110…