🔪 Open 🔦 Laparoscopic 🤖 Robot Pancreatoduodenectomy Randomised Controlled Trials 🧮 Network Meta-Analysis on 7 RCT 1.3 K patients 🔦 LPD ⬇️ LOS and blood loss vs. OPD 🔪 OPD ⬇️ OR time vs. LPD 🤖 RPD similar OPD but data preliminary.. 🫵 Surprised? journals.lww.com/aosopen/fullte…

Ants making a smart maneuver

It’s crazy how talking with a science buddy is simultaneously what’s most likely to move the project forward and the thing that’s least prioritized in our schedule.

Cure Probabilities After Resection of Pancreatic Ductal Adenocarcinoma: A Multi-Institutional Analysis of 2554 Patients. journals.lww.com/annalsofsurger…

Perioperative Corticosteroids 💊 to reduce complications in pancreas surgery ?! 🧐 Meta analysis 5 studies / 1.4k pts Corticosteroids 🫸🫷 not associated to a decrease in morbidity / fistula / mortality 💡 What about mitigation strategis in high risk!? link.springer.com/article/10.124…

Lung only metastatic PDAC 🫁 Better survival than liver! In Nature Cancer 🧬 a primary organotropism (pORG) gene set analysis 👮 Lung-avid/liver-averse tumors associated with active tumor immunity / less replication stress 😥 🤌 Your policy!? nature.com/articles/s4301…

Clinical efficacy of pancreas-preserving distal pancreatectomy for the treatment of pancreatic ductal adenocarcinoma ⁦SURGERY Journal⁩ surgjournal.com/article/S0039-…

Use of aspirin 💊 to lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus 🇭🇰 15 years / 350k pts / 0.2% died of PDAC 💡 Aspirin associated to ⬇ mortality, cancer related and PDAC 🍭 Indicated for T2DM!? 🧐 gut.bmj.com/content/early/…

New RCT: Antibiotics vs appendectomy for uncomplicated appendicitis in children ❌Failure: 34% antibiotics vs 7% appendectomy ❌With 20% (!!) non-inferiority margin 👉 Antibiotics inferior ❌4 times more mild-moderate adverse events in antibiotic group thelancet.com/journals/lance…

Thermal ablation🔥 vs surgery🔪 for small-size colorectal #liver metastases? COLLISION: today ⁦The Lancet Oncology⁩ “The assumption that thermal ablation should be reserved for unresectable CRLM requires re-evaluation” thelancet.com/journals/lanon…

January Issue: Neoadjuvant Treatment with Changes in #ChemotherapyRegimens According to Carbohydrate Antigen 19-9 Level for Resectable/Borderline Resectable #PancreaticDuctalAdenocarcinoma rdcu.be/d6Xmg David Caba MD,MS,MPH,FACS Syed A. Ahmad

🟢 Adjuvant chemo after resection of PDAC following preop FOLFIRINOX 700 patients 💉 2-11 FOLFIRINOX 🔪 surgery localized PDAC 💉 adjuvant chemo 👍 Adjuvant multiagent chemo improved survival ❌ Single agent did not 🔑 RCT needed !!! jamanetwork.com/journals/jamao…

How do costs of robot 🤖 vs open pancreatoduodenectomy compare? Will costs become similar over time? 588 pts A’dam 🇳🇱 (214 RPD, 374 OPD) ⛔️Overall, costs €4,804 ⬆️ for RPD (€27,307 vs. €22,503, P=0.010) ✅Outcomes RPD improved in the 2nd half experience (n=107): hospital

Robotic pancreatoduodenectomy (RPD) outperforms laparoscopic (LPD) in operative time, conversion rate, & blood transfusion, with similar oncologic outcomes. In experienced hands, both are safe. journals.lww.com/annalsofsurger…

Advancing pig kidney xenotransplantation: Improved gene editing and immunosuppression suggest it's time for pilot clinical trials to tackle the organ shortage. Ethical frameworks and careful patient selection are essential for success. journals.lww.com/annalsofsurger…

The PAncreatic surgery Composite Endpoint PACE – Development and validation of a clinically relevant endpoint requiring lower sample sizes. journals.lww.com/annalsofsurger…

Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study ⁦BJS⁩ academic.oup.com/bjs/article/11…

New 🇫🇮🇳🇴RCT out JAMA Surgery 🔥 Results from antibiotics layer of the PERFECT trial: Antibiotics or no while awaiting for appendectomy for presumed uncompl appendicitis 1797 patients Perforations: 8.3% vs 8.9% Surg site infections: 1.6% vs 3.2% (p=0.03) jamanetwork.com/journals/jamas…

Do you offer #video #consultations to your patients when explaining and consenting to major abdominal (eg #pancreas #liver #esophageal surgery? Today in The Lancet Digital Health our multicenter non-inferiority randomised #VIDEOGO trial, including 112 surgical patients. First RCT done in

Clinical implications of postoperative hyperamylasemia and postpancreatectomy acute pancreatitis after pancreatectomy: A systematic review and meta-analysis surgjournal.com/article/S0039-… thank you Giovanni Marchegiani Università di Padova for another excellent open access SURGERY Journal publication