New instrument alert! Our newest addition, the Nikon Instruments point-scanning AXR #confocal, also equipped for TIRF, is up and running! Full information about the instrument and use/trainings can be found here: confocal.uconn.edu/nikonaxr/

Hello Twitterverse - UConn COR²E is now on Twitter! We are a thriving OVPR Center located on the Storrs academic campus comprised of 11 unique core facilities that boast diverse capabilities and expertise. We exist to support the equally diverse UConn research community!

Happy #FluorescenceFriday! The ALMF Core has been busy the past few weeks, so we have some repeat images collected on our Leica Microsystems SP8 with different LUT displays. We're also interested in some robust specimen slides for practice, so if anyone has recs please comment 👇

COR²E has many important updates to share with the UConn research community: recently completed projects, state-of-the-art instrumentation installations, and new people! Read all about them in our brand new Summer 2023 COR²E newsletter here: core.uconn.edu/wp-content/upl…

Having fun with our new Nikon Instruments AXR confocal and using the NIS Elements movie maker function. This is a 3D reconstruction of the crypts in a mouse intestine section showing goblet cells (blue), nuclei (green), and actin (red).#confocal

The value of machine learning using ZEISS arivis 🔬 software for segmentation becomes clear in a sample with high dynamic range, such as this mitotic spindle (bottom). Most of the dimmer astral microtubules are lost with traditional segmentation algorithms (top).

Happy #FluorescenceFriday! We've been playing around with large image + z-stack using JOBS on the Nikon Instruments AXR, which is super useful! Image 1 is a 2D overview, and 2 & 3 are max projections from select regions of this kidney section at 40X.

Happy #MicroscopyMonday! Here we have a fern rhizome imaged with a color camera on a Leica Microsystems Thunder without (Left) and with (Right) a DIC prism in the lightpath, creating interference that results in other colors.

If you're a lab at UConn or @UConnHealth there's still a few weeks left to apply for internal funds if you want to try out one of the UConn Core facilities!

This #FluorescenceFriday we bring you some fun #sciart of a "microscopic sunflower," found from a hibiscus sample! Captured using green and far red fluorescence (yellow and orange here, respectively) and DIC on our Leica Microsystems Thunder. Any #plantsci people able to ID this?

Double dipping on this same stellate trichome (left) for #microscopymonday! This image is using the Leica Microsystems Thunder K5C color camera and applying extended depth of focus. We also imaged part of the stem itself (right) and found other interesting structures!

Want to see more of the core facilities that UConn Storrs and Health have to offer? Register for the Open House! Free lunch with registration, and vendors will be here too!

The Advanced Light Microscopy Facility will be holding a one day workshop on image analysis using the free program ImageJ. It will be held on January 9th and is open to all members of the UConn community. Information and registration can be found at confocal.uconn.edu/analysisworksh…

According to Dr. Chen, “we developed a nanoparticle-based therapeutic for treating osteoarthritis. Our nanoparticles have a unique nano-rod shape, enabling better penetration into articular cartilage compared to traditional spherical nanoparticles.