rSAM, XncB involved in the xenorceptide biosynthesis. This is my third paper from Brandon Morinaka Lab. We further investigate XncB and discovered oxygenated products | ACS Chem Biol pubs.acs.org/doi/10.1021/ac…

Virus-encoded glycosyltransferases hypermodify DNA with diverse glycans dlvr.it/TC6Z66

pubs.rsc.org/en/content/art… Happy to share our latest article on the biosynthesis of the corallorazine lipodipeptide antibiotics in RSC Chemical Biology. Great collaboration with Tanja Schneider! Congrats to talented first author Teresa who did most of the work in her Bachelor! thesis.

Catalytic asymmetric dearomatization is a powerful tool to convert flat aromatic compounds into 3D scaffolds. However, catalytic asymmetric dearomatization via a radical mechanism is difficult. We provide a new biocatalytic solution: nature.com/articles/s4155…

The Dickinson Lab is advancing precision medicine with covalent macrocyclic peptides, paving the way for new targeted therapies. Read the full story by visiting our website. bryan dickinson J. Am. Chem. Soc. Tong Lan UChicago News UChicago Biological Sciences UChiPhysicalSciences chemistry.uchicago.edu/news/improving…

Out now in Chem , we collaborate with Piel Lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to Florian Hubrich, Sanath Kandy for leading this!🎉authors.elsevier.com/c/1jjdi8jWHELG…

Efficient genetic code expansion without host genome modifications go.nature.com/3MDSSXQ

Escape from drimane: We designed rearrangement approaches to convert sclareolide to 4 known terpene skeletons with differing skeletal connectivity, resulting in the syntheses of 4 natural products. chemrxiv.org/engage/chemrxi…

Here, the authors identify key molecular interactions that guide lasso peptide folding and cyclase substrate tolerance, informing cyclase engineering for expanded lasso peptide diversity and #PeptideEngineering & #DrugDesign Chemistry at Illinois Read it here rdcu.be/dTLyo

Delighted that a collaboration with Satish Nair is now online Nature Chemical Biology Nucleobases are common in biology but not in peptides. In this work, a nucleobase-peptide hybrid is generated from a ribosomal precursor peptide via YcaO domain protein catalysis. nature.com/articles/s4158…

Excited to announce our new paper from Brandon's lab is now published in Nature Chemistry, in great collaboration with Prof. Nicolet & Prof. Zhang's groups! Huge thanks to Suze Ma & Eugenio as co-first authors ,and all the co-authors for this publication! nature.com/articles/s4155…

#WeekendReading! We've been loving #ChemRevs content this week 💅 Noncanonical amino acids are so hot right now 🔥 Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis ➡️ go.acs.org/b8j Cool work from Brouwer et al. 👏

We developed a versatile genome mining strategy to explore the biosynthetic space of the atropopeptides - a fascinating family of peptides with complex 3D shapes! Now out in Chemical Science #peptides #biosynthesis #genomemining pubs.rsc.org/en/content/art…

Modifications of Prenyl Side Chains in Natural Product #Biosynthesis by Huibin Wang, Yi Yang, and Ikuro Abe in Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

Excited to share our latest preprint of using 19F solid state NMR to study conformational dynamics of GPCRs. A huge thank you to Beining Jin and Matthew Eddy for all the support. biorxiv.org/content/10.110… #NMR #Membranemimetic #liposome #ssNMR #GPCR

We studied rSAM, HtkB catalyze a His-to-Lys crosslink, and revealed conserved active site residues that influence substrate specificity. Brandon Morinaka Lab | RSC Chem Biol doi.org/10.1039/D4CB00…

The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! Beilstein-Institut @beilstein-institut.bsky.social beilstein-journals.org/bjoc/series/129

Antibiotic discovery is notoriously hard and slow. What if we could change that by optimizing antibiotics on the computer? Introducing APEXgo, our latest AI model, which integrates a transformer-based variational autoencoder with Bayesian optimization to design novel

Online now! Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7 dlvr.it/TJ5GKp

Catalytic Enantioselective Smiles Rearrangement Enabled by the Directed Evolution of P450 Radical Aryl Migratases by Wenzhen Fu, Katherina Murcek, Jasper Chen, An Liu, Yunlong Zhao, Peng Liu (Peng Liu Group), and Yang Yang (Yang Yang) in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…