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Glad to share our new study on microglial TREM2 clearance of TDP43, published today in Nature Neuroscience. We found that TDP43 directly binds TREM2. Tremendous efforts led by Manling and Yong with strong support from guojunbulab, Mark Mattson and many others. nature.com/articles/s4159…

TDP-43 binds to #microglial TREM2 and that this interaction mediates neuroprotection of microglia in TDP-43-related neurodegeneration #ALS go.nature.com/30ysg6j

Fantastic news reports from Discovery's Edge @mayoclinc as well as from BioArt BioArt on our work regarding microglial TREM2 in TDP-43 neurodegeneration Nature Neuroscience. Extremely grateful to Sara Tiner for writing up the story! discoverysedge.mayo.edu/2021/12/16/dis…

Very much appreciate The Colonna Lab for insightful comments! We indeed collaborate with Dr Bo Liang at Emory on crystal structure of binding. Thanks Dr Shugart Alzforum for writing up the news story!