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Dear Participants of the NAI Meeting 2022, dear Speakers, dear Participants, thank you all for this great meeting. We hope to meet you again at the next conference on #NucleicAcidImmunity! #Immunology #NucleicAcids Rheinische Friedrich-Wilhelms-Universität Bonn Medical Research Council

Impactful words by Carolyn Bertozzi today on how diversity in her trainees enabled creativity, not playing by the rules, and ultimately the work that built the field of bioorthogonal chemistry. Diverse science leads to better science!

We are looking for an enthusiastic #PhD student and #postdoc to join our team at the Institute of Innate Immunity. Come and join us if you are interested in an interdisciplinary environment, studying cell fate and function in tissue environments including lots of cool #cilia stuff ImmunoSensation

Are you interested in inflammasomes and biochemistry? Then this one might be for you: we investigated the common NLRP1 variant M1184V. Directly comparing it to the wt protein we found that it stabilizes the FIIND domain, leading to increased autoproteolysis and DPP9 binding...

Lea Jenster, Elmar Lange, Sabine Normann, FISchmidtLab & colleagues identify #p38 as the common integrator for cellular stress in keratinocytes by UV and #alphavirus infection, activating #NLRP1 #inflammasomes by direct phosphorylation. bit.ly/3zvaf6S Institute of Innate Immunity Rheinische Friedrich-Wilhelms-Universität Bonn

Timely read for halloween: #keratinocytes die with a blast: #UVB and #alphavirus infection activate #p38, which phosphorylates #NLRP1 and triggers #inflammasome activation in a novel way. Great work with Meissner_Lab Institute of Structural Biology Bonn and Kuemmerer lab. Of course with #nanobodies.

We are very pleased to announce that our Collaborative Research Center 𝙉𝙪𝙘𝙡𝙚𝙞𝙘 𝘼𝙘𝙞𝙙 𝙄𝙢𝙢𝙪𝙣𝙞𝙩𝙮 CRC Transregio 237 is going into the next funding round. 🥳 Many thanks to all our members and our partner universities TU Dresden, Rheinische Friedrich-Wilhelms-Universität Bonn & Universität München.

It is APPROVED! The #DFG prolonged our CRC237 Nucleic Acid Immunity for a second term. Congratulations to all involved, the speakers, the PIs, and the researchers!

📣PhD Jobs: We are doing another round of interviews for available #phdpositions in our lab in January. Please RT and spread the word to #RNA enthusiasts. Contact and apply to: kleppek (at) uni-bonn (dot) de #phdjobs

New compound inhibits influenza virus replication: Derivative of a bacterial natural product blocks endogenous methyltransferase. Study by researchers ImmunoSensation published in Science Magazine. Read more: science.org/doi/10.1126/sc… & uni-bonn.de/en/news/016-20…

Today the institute is taking a brief science pause to celebrate Karneval 🎉 🥳 The III says Alaaf 🥳

A late entry from FISchmidtLab Showing expert coordination this year, winners of best group costume 🐶

We are super excited to share the newest publication from the Latz Lab Institute of Innate Immunity in Nature Immunology 🔥🎉 nature.com/articles/s4159… A great collaboration with Franklin Zhong and FISchmidtLab Summary below, from twitterless 1st author Tom... 1/n

Want to work as a #postdoc on #optogenetics and tool development, funded by a grant from ZIM - Zentrales Innovationsprogramm Mittelstand - come and join our team at the Institute of Innate Immunity ImmunoSensation

Weekend reads! Check out our preprints on #GSDMD pore formation. We generated #nanobodies and used them to dissect the steps of pore assembly (and more) in living cells, Anja Kopp Institute of Structural Biology Bonn solved structures (and more) Rheinische Friedrich-Wilhelms-Universität Bonn biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Little teaser: this is how #GSDMD localizes to the plasma membrane when oligomerization and pore formation is inhibited. Institute of Innate Immunity Uniklinik Bonn

A ride with a quick “media change” stop.

Open positions alert! Great opportunities!

Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy. nature.com/articles/s4146…