Twitter Beğeni Hilesi

An oncolytic virus–T cell chimera for cancer immunotherapy go.nature.com/48aEcIe

Zhejiang University University of Chinese Academy of Sciences Research Highlight: Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic, in Signal Transduction and Targeted Therapy(STTT) nature.com/articles/s4139…

Congrats to Jinchao Hou (JinChao Hou) and Yun Chen. Our new study highlights the role of LILRB4 inhibition in enhancing microglial function and reducing amyloid-β accumulation, suggesting LILRB4 as a potential treatment target for AD. science.org/doi/epdf/10.11…

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/ nature.com/articles/s4158…

This is so cool! Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior biorxiv.org/content/10.110…

Excited to share that our paper is now out in Nature Communications! We explore how CAR affinity influences CAR-T cell sensitivity to PD1/PD-L1 inhibition. Huge congrats to Irene Andreu and Alba Rodríguez for their exceptional work! IDIBAPS Hospital Clínic doi.org/10.1038/s41467…

Beautiful structural work revealing a trimeric assembly of MHC-II with invariant chain, led by Nan Wang from the Garcia lab. Amazing to visualize this critical step in antigen processing 😍 pnas.org/doi/10.1073/pn…

The structure probably will be included in the updated text book! Congrats to Nan Wang for publishing this beautiful work from Garcia lab!

Our new paper on “synpoptosis” circuits, led by the amazing Shiyu Xia, is now out: sciencedirect.com/science/articl… (1/3)

In our new preprint, we leverage #structures of #TCR:pHLAs to classify #HLA molecular surfaces into T-cell cross-reactivity groups (T-CREGs). We apply our analysis to suggest #patient cohort expansion of existing TCR #immunotherapy treatments. biorxiv.org/content/10.110…

lets try this again -We are searching for #postdocs with deep #expertise in #Tcell #biology #structuralbiology #mutagenesis #invivo #editing #antigen #recognition. Please contact if you are #interested!

Great review! So much to learn from tissue-resident immune system. Congrats! Ming Li

(1/7)Excited to see our latest manuscript in press at JCI insight (doi.org/10.1172/jci.in…)! This was a great extension of our continuing multi-institutional, multidisciplinary group to better understand pathogenic CD8 T cells in #axialspondyloarthritis & anterior #uveitis.

Super interesting story from Michael Paley. I am so glad to be part of this work!

NEW Review online: CD28 co-stimulation: novel insights and applications in cancer immunotherapy bit.ly/46qtBcP by Michael Lotze University of Pittsburgh, Scott Olejniczak Roswell Park & dimitris skokos Regeneron discusses CD28 as central to the success of current and future therapy

I love stories like this When the results of a new drug that prevented 100% of HIV cases were announced at the 2024 AIDS conference, the room burst into spontaneous applause

An enteric start to HLA-B27-associated autoimmune disease? insight.jci.org/articles/view/… Work from Michael Paley, M.D., Ph.D., Xinbo Yang et al. suggests early antigen exposure in gut leads to pathogenic CD8+ T cell development in axial spondyloarthritis & acute anterior uveitis. Test Account

A long waited and must see structure! Congrats to Luca lab!

T cell engagers for autoimmune disease 💥 Happy to share our latest study demonstrating the feasibility of the CD3xBCMA T cell engager Teclistamab in patients with refractory Systemic sclerosis, Sjogren‘s syndrome, Dermatomyositis and Rheumatoid arthritis. nejm.org/doi/full/10.10…

Microglia serve as conduits for the export of toxic protein aggregates from neurons and the import of healthy organelles, keeping neurodegeneration at bay go.nature.com/4dXkIuh