3 years ago we lost an amazing person and great scientist, but his legacy still lives on in the community he left behind—Bar-Even Lab organized an elegiac yet cheerful homage to Arren as his group moves onto new endeavors. Honored to be part of this extended family🌱

📢The C1 Metabolism group DTU Biosustain is recruiting! We are looking for a Postdoc (shorturl.at/wFNR8) and a Research Assistant (shorturl.at/dJKU1) to join us in our mission to understand and engineer microbes that grow on C1 substrates. Please share!

🚨New paper! In our article, together with Pablo Iván Nikel @pabnik.bsky.social, Lars Nielsen and Stefano Donati, we discuss current state of investigation of #natural and #synthetic C1-trophic bugs, proposing that these approaches can synergistically help each other's👇🧵[1/n] doi.org/10.1038/s41467…

Congratulations to Helena Schulz-Mirbach on winning the add-on #fellowship of the Joachim Herz Stiftung! Helena plans to use the fellowship to gain additional computational expertise which would help to systematically find bottlenecks in engineered synthetic #CO2 fixation by E. coli.

Happy to share our new design of a C1/formaldehyde assimilation pathway out on Nature Communications. Congrats to Tong Wu and all. Thanks to supports from Bar-Even Lab, Philippe Marliere, @SteffenNLindner, and SYBORG! #MetabolicEngineering #SynBio nature.com/articles/s4146…

Very cool to see this work out! Another promising new to nature/not yet discovered in nature C1 fixation pathway from the Bar-Even Lab led by HaiHe Tong Wu

I am happy to share our publication demonstrating the functional Reductive Glycine Pathway (RGP) in S. cerevisiae, presenting evidence for nearly complete glycine and serine flux and partial pyruvate flux from formate coupled with CO2 co-assimilation is recently published.

Finally out the work led by Viswanada Reddy Bysani Kondagari, Ph.D. and Fabian Machens about the engineering and evolution of the rGP to support formate-to-pyruvate conversion in S. cerevisiae! Check it at the link: sciencedirect.com/science/articl…

Great group and great science! Check out this #postdoc opportunity in Berlin together with former core members of Bar-Even Lab 🫶

I am not crying, you are crying! What a special beginning of day 2 The Carbon Recycling Network ❤️❤️❤️ Bar-Even Lab

Very happy I was awarded this week the ' Kluyver Award' by the board Royal Dutch Microbiology Association (KNVM ) for my contribution (or better our!) to microbiology, sustainable biotech, teaching and mentoring activities. Thankful to many advisors, colleagues, students

#Automated in vivo #enzyme #engineering accelerates #biocatalyst optimization — Led by Enrico Orsi & @SteffenNLindner w/Lennart Schada von Borzyskowski & Stephan Noack Nature Communications #SynBio #CellFactory nature.com/articles/s4146…

Obtaining efficient #catalysts is one of the core challenges of #bioengineering. However, combination of existing #SynBio, #computation & #automation techs can boost the way we generate these catalysts. Check this 🧵 to learn more! (1/n) nature.com/articles/s4146…

This nice work is the result of a team effort involving experts of different aspects of the whole workflow: Lennart Schada von Borzyskowski, Stephan Noach, Pablo Iván Nikel @pabnik.bsky.social and @SteffenNLindner. We believe that this can be a useful read to synbio, enzymologists and automation experts! (n/n)

How can lab automation, machine learning, and high-throughput screening methods be combined to speed up the enzyme engineering process? We address this question in a new article in Nature Communications, out today: nature.com/articles/s4146…

We propose to combine machine learning with automated workflows and efficient selection processes in engineered bacteria to address challenges in enzyme engineering. By following this integrated approach, we aim to engineer enzymes faster and more reliably than before.

Citius, altius, fortius: Automated in vivo enzyme engineering accelerates biocatalyst optimization 👇 nature.com/articles/s4146…

Happy to share our curated medium-scale E coli metabolic model out. We believe it has many application potentials, a few demonstrations shown in our preprint arxiv.org/abs/2406.16596 check it out. Great job by Marco! #Synbio #metabolism Bar-Even Lab

Harnessing the high product titers from fermentations for aerobic productions? Metabolic rewiring makes that possible! Read below to get to know my NNmini strain allowing the selective use of respiratory modules to re-balance unbalanced fermentations! nature.com/articles/s4146…

Amazing job by a whole gang of previous AG Bar-Even members Bar-Even Lab who converted E. coli into glyoxylate growth biosensors for enzyme engineering!