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Wonderful collaboration with Aleksandra Filipovska reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. Science Magazine science.org/doi/10.1126/sc…

We (with Kiarash Jamali and Dari Kimanius) present #ModelAngelo version 1.0 for automated model building of proteins and nucleotides, as well as protein identification in #cryoEM maps. A #tweetorial below. biorxiv.org/content/10.110…

Congratulations, Takanori

🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with Eva Absmeier, Lori Passmore & Ivana Gasic 🧵 1/ cell.com/molecular-cell…

Excited to share our latest work on bioRxiv! We visualised single molecules of dynein and its cofactors live in the axon. Work by Alex Fellows in collaboration with the Wellcome Sanger Institute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold) biorxiv.org/content/10.110…

So happy to finally be able to share my post-doc work! I just want to say a massive thank you to everyone who has helped/supported me during this project.

Exciting #postdoc opportunity with Lori Passmore to study transcription and mRNA processing using cryo-electron tomography and single particle cryoEM: nature.com/naturecareers/… Deadline: 15 SEP #PostdocJobs #ScienceJobs Please RT!

Here's a NSMB Research Briefing summarising this work, with Lori Passmore rdcu.be/dlvyE (Also visit Poster 99 tomorrow at the Protein synthesis and translational control EMBL conference #EMBLprotein)

Excited to see fruits of a huge community effort! Thanks to Dr. Tijana Milenkovic for the leadership and the opportunity to be a part of this 🙌🏽

Available now - the Review "#Cotranslational sorting and processing of newly synthesized proteins in eukaryotes" from Martin Gamerdinger and Elke Deuerling Lab. #NacentpolypeptideAssociatedComplex #SignalRecognitionParticle #RibosomeAssociatedComplex authors.elsevier.com/a/1i0Wg_M0e48h…

We have some very exciting projects on mechanisms of DNA repair in the lab! Come join our team 🧬!

A subset of polytopic membrane proteins, such as subunits of the GABAA receptor, remains incompletely inserted when translation is terminated. We describe an essential post-translational step that completes insertion of such proteins. nature.com/articles/s4159…

I am thrilled to share our manuscript published in Nature Reviews Molecular Cell Biology. In this Review (Brito Querido et al., 2023), we discuss the current state of knowledge on eukaryotic translation initiation and its regulation in health and disease.

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

I am thrilled to share our new paper published in NatureStructMolBiol (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. #Ribosome #mRNA #Science nature.com/articles/s4159…

🥳Thrilled to share our new paper describing Balon, a bacterial ribosome hibernation factor that resembles aeRF1 family proteins. Fantastic collaboration with Karla Helena Bueno Sergey Melnikov and Mariia Rybak 🇺🇦 Matthieu Gagnon nature.com/articles/s4158…

We have optimized a human in-vitro translation system (HITS) for use in #ribosome research Our HITS: 🧪requires a minimal number of components 💵is cheap & easy to prepare 💡enables cap-dependent translation 📈is highly active online now: bit.ly/49xTdVa Cell Reports Methods

We’re excited to share our study in Cell on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by Niladri Sinha! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/…

The last time MRC Laboratory of Molecular Biology team won the interdepartmental cricket cup John Walker was playing in the side! (1982 we think.) Great game against Chemistry, very close!

The Pitchiaya lab is #hiring! We seek to hire a #Postdoc to work on exciting projects pertaining to stress response mechanisms in cancer - bit.ly/46jzBE8. Email/DM for more info. Michigan Pathology U-M Rogel Cancer Center UMich RNA Center 〽️🧬 Michigan Research Michigan Medicine