Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies biorxiv.org/cgi/content/sh… #bioRxiv

New preprint from our lab; Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies biorxiv.org/cgi/content/sh… #bioRxiv

A new preprint from Saravanabhavan Thangavel lab is online! Our work focuses on creating an 11kb HPFH-like deletion for the gene therapy of β- hemoglobinopathies. biorxiv.org/content/10.110… CRISPR News 🧬 Hematopoiesis Hematopoiesis News

The journey of my paper 😭 #phdlife #phdchat #phdmemes PhD_Genie PhD Voice - Independently Run

Accepting and rejecting papers is an archaic practice that is terrible for science. It strips peer review of its value & institutionalizes the practice of judging scientists based on where, rather than what, they publish. It's time for this system to go. elifesciences.org/articles/83889

What should stable surveillance be? All cause severe acute respiratory infection surveillance at all or sentinel hospitals (depending on resources), detection & investigation of clusters. Periodic serosurveys & environmental surveillance can be useful depending on pathogen. 17/n

The video version of our protocol for hematopoietic stem cell gene editing and transplantation is out now! jove.com/t/64064/crispr… Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem Department of Biotechnology JoVE #genetherapy #CRISPR

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies dlvr.it/Sn9NPV #MTNA

Finally this work found its home Molecular Therapy #MTNA CRISP_SCIENCE CRISPR News 🧬 CRISPRpapers Thalassemics India Sickle Cell Society

Farewell party for our beloved Abhirup Bagchi who will be joining blobellab soon. Both of my favourites are joining together 🤩. Ready to witness some cool science in the upcoming days ✌🏻.

Picture of the DAY!! InStem- ARR2023 #Day1 Department of Biotechnology iBRIC-inStem Centre for Stem Cell Research _ CMC _ inStem

You won Prathibha !!! As a Naruto fan, I suggested some cool ninja-based cartoons for the cover page - like a ninja making a cut with the katana in the genome to create an HPFH deletion. Didn't work out in the end.🤣 Now added to my bucket list. やってみましょう

Super pleased to see this out now in Nature Communications 🎉 - it's been a big team effort to get to this point! Give it a read if you're interested in beta thalassemia and cellular model systems for red blood cell diseases 🩸🧫🔬 nature.com/articles/s4146…

I am truly honored and deeply grateful to have been selected as a recipient of the prestigious Sun Pharma Science Scholar Award. Dedicating this award to Saravanabhavan Thangavel and the team for their constant support. Thanks to Sun Pharma for giving me this opportunity.

I’m excited to share our latest study led by Giulia Pasquesi out today in Cell Press , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

New publication from our lab showing therapeutic dual-beneficial mutations gene editing for the gene therapy of sickle cell disease and β-thalassemia. stemcellres.biomedcentral.com/articles/10.11… Department of Biotechnology Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem CMC Vellore (Official) Prathibha #SickleCellDisease #GeneTherapy

Our work and my first author article is online now. We describe our therapeutic editing strategy for treating β-hemogobinopathies. Happy reading and a very happy new year :) stemcellres.biomedcentral.com/articles/10.11… Saravanabhavan Thangavel Vigneshwaran Venkatesan Centre for Stem Cell Research _ CMC _ inStem BMC #CRISPR #GeneTherapy

The gut microbiome signature from different diets in >20,000 individuals. Red meat intake correlated with reduced cardiometabolic health; the opposite for plant-based foods or in omnivores with enriched plant-based intake nature.com/articles/s4156… Nature Microbiology Nicola Segata

Check out our latest review article, where we dive into recent innovations in gene editing technologies. Published in Advanced Science doi.org/10.1002/advs.2… Centre for Stem Cell Research _ CMC _ inStem iBRIC-inStem Department of Biotechnology #geneediting #genetherapy

You're not depressed, you just lost your quest.