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The #CZImagingInstitute Kaggle Challenge is now open worldwide! Help accelerate biomedical discovery by developing #ML algorithms to automate the detection of biological objects in 3D images of cells captured by #CryoET czi.co/3Zdex04

Diacylglycerol (DAG): A simple #lipid with complex roles! 🧬From #membrane shaping to #cellularsignaling, DAG is a key player inside the cell. Our review explores DAG #metabolism and #regulation in yeast models 👉 doi.org/10.1093/femsyr… Sankar's Lab Sankaranarayanan Rajan Biswajit Pal

Discover the fascinating world of #DAGs !! These seemingly simple lipids play crucial role in myriad cellular processes. Our latest review delves into the intricacies of DAG metabolism and regulation in yeast. Sudipta Mondal, PhD Biswajit Pal Sankaranarayanan Rajan CCMB doi.org/10.1093/femsyr…

We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics

1/n) Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and Alan Brown nature.com/articles/s4158…

A collaborative study with Sankaranarayanan Rajan’s lab CCMB led by Sakshi Shambhavi & Sudipta Mondal, PhD is now available as a reviewed preprint eLife - the journal. Arnab Chakraborty from our lab IISER Pune contributed with DAG measurements in this study. elifesciences.org/reviewed-prepr…

2025 kicked off on a high note with this incredible symposium! 🌟 incredible speaker lineup—couldn't ask for better! #CryoEM #cryoET

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — watch it crack that gate! 🤯 💥 Incredible work from Beck Laboratory and Hummer Lab 🤩 More here: biophys.mpg.de/2842024/hivcap… 🔗

ASBMB's Lipid Research Division seminars return tomorrow! Register to join us at 12 p.m. Eastern for "Homeostasis of sphingomyelin synthesis and subcellular distribution." Check out the speaker lineup too: ow.ly/63wU50UPa4M.

The EMBO workshop on Host and Pathogen Heterogeneity in TB started at CCMB today. The next 4 days, we will see multiple perspectives to understand how the TB pathogen, Mtb infects and how to stop the infections. CSIR, India EMBO Events A*STAR Infectious Diseases (ID) Labs ICGEB, New Delhi Institut Pasteur, since 1887

Had a great experience attending and presenting my work at the EMBO Events #EMBOtuberculosis conference at CCMB ! Engaging talks, insightful discussions, and great interactions—plus the bonus of catching up with my alma mater! #TB #phage

The architecture, assembly, and evolution of a complex flagellar motor biorxiv.org/content/10.110…

Cool stuff

Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Gordon Research Conferences Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers… Raphael (Donghyun) Park

Scripps Research and University of Pittsburgh capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per Cell. More: scripps.edu/news-and-event…

Can the same #lipid do two different jobs- signalling and #metabolism - just by tweaking its tail length? 🤔 Turns out #evolution figured this out ~1.2 billion years ago! 🔥 Folks (including me) at the Sankar's Lab took a DIP and uncovered some cool insights #lipidtime