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Excited to share our work on genome editing for SMA in Science Magazine! We evaluated dozens of strategies targeting SMN2 regulatory sequences to rescue SMN levels, and show that one-time in vivo co-administration of our top strategy with nusinersen extends lifespan of SMA mice.

New Posthuman Research Group Die Junge Akademie! In a world in which the human is called into question by crises and innovations, do categories of consciousness and subjectivity need to be renegotiated? Sarah Kim-Hellmuth Birgit Nemec 🦠 diejungeakademie.de/de/arbeitsgrup… #morethanhuman #nonhuman

Isis Fernandez Universität München Helmholtz Munich | @HelmholtzMunich Institute of Lung Health and Immunity @LMU_Uniklinikum MariSubklewe MCSP - Munich Clinician Scientist Program LMU Inga Koerte Baldauf Lab Inspirational meeting and discussion Sarah Kim-Hellmuth. Many thanks for the invitation Susanna Hofmann!

So excited to see this out! Check out our review: single-cell genomics meets human genetics 🧬 Was so fun to write this and think about where the field is going. Wonderful team work with Aparna Nathan Soumya Raychaudhuri সৌম্য রায়চৌধুরী Daniel MacArthur Joseph Powell

And here it is, now peer-reviewed and open access Oxford Journals. Thanks to all reviewers for very constructive feedback, as well as Axel Schmidt, Hannah Klinkhammer and Martin Kircher for taking the paper over the finish line. 🥂 academic.oup.com/bioinformatics…

Im Rahmen des #salonsc am 13.05. lädt die Junge Akademie zum Thema "Künstliche (Un)Vernunft" #KI ein bit.ly/3HvovAE Mit Andrea Binder, @J_GurolHaller, Sebastian Hellmeier, Anne Hemkendreis, Sarah Kim-Hellmuth, Jakub Limanowski, Kerstin Maria Pahl, Kai Siedenburg, Mira Sievers & @Leonie_Climate

So excited that our exhibition on AI-generated images will open next saturday in Berlin! Come and visit us and the other exciting sections! 👾@klipphahnkarge @Leonie_Climate Jakub Limanowski Sarah Kim-Hellmuth Die Junge Akademie #posthuman #ArtificialIntelligence #bbaw #posthumanart

Es ist da🎉 ! Die Junge Akademie veröffentlicht gemeinsam mit Hanser Literatur das #Kinderbuch "Young Scientists - 30 Forschende und ihre Wege in die #Wissenschaft". Ab dem 15. Mai im Handel erhältlich. Pressemitteilung und weitere Infos 🔗bit.ly/3LMZLoN #Karrierewege

Check out our latest paper in nature! We unveil the fascinating variation of individual polygenic scoring accuracy across the genetic ancestry continuum!

Hot off the press! 📢✨ Check out our in-depth review on “Methods and Insights from Single-Cell Expression Quantitative Trait Loci” 🧬📖! Annual Reviews Had a great time writing with Alessandro Raveane Aparna Nathan Nicole Soranzo Soumya Raychaudhuri সৌম্য রায়চৌধুরী annualreviews.org/doi/abs/10.114…

Long reads are one of the greatest innovations for RNA profiling as they help to identify individual isoforms. But… what about long reads that don't perfectly match reference annotations? Very happy to share our answer to this question - bambu! nature.com/articles/s4159… 1/n

What an exciting week for ITG as our Comment on the use of WGS for human complex traits together with Eleftheria Zeggini and Cristen Wiles is out in Nature Communications ! nature.com/articles/s4146…

Excited to share a new preprint from my lab, led by Silva Kasela ✨, analyzing cellular and environmental modifiers of regulatory variants in the TOPMed multi-omics pilot data from the MESA cohort. 🧵biorxiv.org/content/10.110…

So excited to share our recent work! 🎉 Just released 2 innovative tools in Nature Genetics: nature.com/articles/s4158… nature.com/articles/s4158… Huge applause to my great team of brilliant researchers who made this possible! Stay tuned for deeper insights.

New paper out Molecular Therapy where we show the development of a peptide drug counteracting #cachexia by targeting AMPK in adipocytes. Great collaboration with groups of O.Plettenburg, S.Herzig (not on twitter) Honglei Ji Helmholtz Munich | @HelmholtzMunich Helmholtz Diabetes Center (HDC) 🫶 doi.org/10.1016/j.ymth…

Was Gene mit unserem Immunsystem zu tun haben, untersucht die Ärztin Sarah Kim-Hellmuth (Sarah Kim-Hellmuth). Sie ist Mitglied der Jungen Akademie und eine von 30 porträtierten Forschenden im Buch „Young Scientists“ von der Jungen Akademie und Hanser Literatur. bit.ly/3lQrJHq

On the problem of inflation in TWAS Does TWAS yield inflated p-values?

Excited to share our review paper in Cell! With Sasha Gusev Sohini Ramachandran Yang I Li we discuss the genetic and molecular architecture of human traits, future opportunities and challenges and ways forward. authors.elsevier.com/a/1igrbL7PXqPfU

Das sind die neuen Innovatorinnen in unserer #ExpertinnenDatenbank - ansprechbar für Medienschaffende, zur Vernetzung oder als #Speakerinnen. Jetzt spannende Innovationen entdecken: innovative-frauen.de/expertinnen #InnovativeFrauen #Innovation