Congrats Jiefu! So happy for you! Look forward to all the great science from Li Lab and hopefully we find something to collaborate again in the near future haha!

As a beautiful sequel to Jiefu Li & Shuo Han’s 2020 Cell paper describing cell surface proteome profiling in vivo, this new paper by ChiChi Xie & Liqun Luo et al. performs cell surface proximity labeling in WT vs. Acj6 knockdown flies, to discover... tinyurl.com/3rrzfccw

Thank you again to all of the attendees Epithelial SCs and Niches GRC! We are building a strong, inclusive, and welcoming community of exceptional #stemcell researchers. It was a privilege to organize this meeting together with Dr. ᐯᗩᒪEᖇIE ᕼOᖇᔕᒪEY 🔬, and I hope to see all of you again in two years.

Highly recommend! Ken is a wonderful scientist and mentor! A fantastic choice if you are interested in applying cutting edge chemical biology tools to studying molecular physiology!

I will start building my lab this summer in the brand new @westlake_uni, and we are hiring at all levels. Come join us to create protein-based synthetic intelligence: chenlab.org

With more grants coming, we are excited to recruit postdocs who are interested in regenerative biology and extreme physiology. Some recent pubs and reviews here: bit.ly/3zqWQtV, tinyurl.com/y72afknn, tinyurl.com/2fp9ppew, tinyurl.com/59xdfjry Please RT.

You know CRISPR complexes can cut DNA/RNA….what if some of them cleaved proteins too? Today in bioRxiv, we (+ Omar Abudayyeh hnisimasu) continue our study of Cas7-11 and type III-E systems, revealing a new triggered protease function biorxiv.org/content/10.110… 1/6

CRISPR can cut DNA and RNA, but did you ever wonder other activities might exist? Today in bioRxiv, we show that the Type III-E Cas7-11 system programmably activates a nearby protease as part of microbial defense. + Jonathan Gootenberg hnisimasu 🧵👇🏼biorxiv.org/content/10.110… 1/9

Thanks a ton to Damon Runyon Cancer Research Foundation for organizing our amazing retreat! Fantastic talks from all fellows and really inspirational career advice from former alum Dr. ᐯᗩᒪEᖇIE ᕼOᖇᔕᒪEY 🔬. Also visited many friends and mentors at MIT Chem first time since I left 2016. See you next time Boston!

Prostate cancer occurs more frequently at the peripheral zone (PZ) than in transition zone (TZ) prostate, but the underlying mechanism is unclear. Study by Dr. Deyong Jia in my lab at Nature Communications provides one explanation for this clinical observation. doi.org/10.1038/s41467…

Woohoo! Big congrats to Jiaqi Shen, Lequn Geng and Xingyu Li for all their collaborative work leading to a brand new publication in Nature Methods! Our group teamed up with Prof Peng Li’s Lab 👏🏻!!! (UMLifeSciences & UM SchoolofDentistry) nature.com/articles/s4159…

Our work on ENTER is finally out Cell! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications: ⭐️Decode Ligand-Receptor interaction ⭐️Receptor-specific cargo delivery ⭐️Link receptor specificity with cell state at single cell

The FASEB BioAdvances journal team would like to welcome new Editorial Board member Shuo Han of the Shanghai Institute of Biochemistry and Cell Biology! Welcome aboard! bit.ly/42Z8OK2 #FASEBBioAdvances

Lots of fun at our first lab outing and my first foray into poetry 😂

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday nature.com/articles/nmeth…

Huge congrats to Chuanyun Xu and all collaborators Broad Proteomics Alice Ting Shuo Han Wu Tsai Neurosciences Institute HHMI HHMI | Janelia! (Sneak in an ad: my lab at Janelia is seeking a highly motivated postdoc interested in kidney physiology. Pls share!) cell.com/cell/fulltext/…

Can we design mutations that predictably bias proteins towards desired conformational states? Today in Science Magazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify

Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states CB part starts at 14:55 youtube.com/watch?v=4v_ZqW… Thanks to Peter E Cavanagh and Andrew Xue – amazing graduate students who