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Nice short/introductory review in all things ribosomes by pioneer Harry Noller in the special 50 years issue of Cell. The ribosome comes to life: Cell cell.com/cell/fulltext/…

How are mRNAs recruited to the ribosome small subunit in bacteria? Super cool story highlighting the role of bS1. Long standing basic questions answered there 🔬 science.org/doi/10.1126/sc…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

The Dept. of Biological Sciences Columbia University is searching for an #AssistantProfessor in #biochemistry. (biochemical/biophysical approaches studying protein/nucleic acid function and dynamics, metabolism, microbial biology, or cancer biology) Please include a 1-page anonymized

For any aspiring structural biologists, the one and only Wayne Hendrickson! Learn from the legend.

Excited to share our work in PNASNews . We report the cryoEM structures of both TRIF and TRAM uncovering the molecular basis of TRIF-mediated TLR3 and TLR4 signalling pathways. pnas.org/doi/10.1073/pn…

UChicago scientists have invented a soft, flexible semiconductor capable of transmitting information from living tissue to electronics. This major bioelectronics breakthrough could lead to better brain-machine interfaces, biosensors and pacemakers. ms.spr.ly/6012UkG8m

Announcing, one of a unique conference. #CellDeath, #Innateimmunity, and #Autophagy. Top speakers, top Science. website -open soon- Please retweet. EMBO DBT/WT India Alliance CCMB CSIR, India Jonathan Kagan Vishva Dixit Vojo Peter Deretic Veit Hornung Thirumala-Devi Kanneganti Clare Bryant ([email protected]) Ivan Đikić

Glad to share our new preprint, structure of the recently discovered Lamassu bacterial defense system, which is related to Rad50/Mre11 (RM). Our study reveals how Lamassu stays sequestered and activated after phage infection.

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in Science Magazine 🎉 You can find the full story here science.org/doi/10.1126/sc… Verena Resch did a wonderful job on the cover and animation👩‍🎨

Out just now at Nature Communications: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: nature.com/articles/s4146…

Excited to share the N&V Roberto Zoncu and I wrote for NatureStructMolBiol on the recent surge of LYCHOS structure papers! 🚀 We propose a unifying model that ties together these new discoveries. It’s incredible to see so much momentum building on our work. nature.com/articles/s4159…

Grappling with poorly-resolved ligand binding sites in #cryoEM maps? Check out our new case study on a peptide ligand-bound GPCR showing how practical tips and features in #CryoSPARC v4.7 improve locally refined map quality & reveal clearer ligand density! guide.cryosparc.com/processing-dat…

~40kDa receptor + ~8kDa ligand - without any fiducial marker, interaction partner, oligomeric state, or symmetry! Stay tuned!

Phosphorylation depends both on the sequence and on spatial proximity in vivo between kinases and their substrates. Both of these factors are accounted for in this preprint 1/2

Structural-functional dissection of arginine sensing by CASTOR1 and its interaction with GATOR2 to regulate mTORC1 signaling, led by Rachel Jansen Hurley Lab lab with help from Z-lab postdoc Clement Maghe: tinyurl.com/yr6en6f4

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…

My lab's first paper is out in nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…

How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…