Here’s the thing: For 35 years, I’ve researched the immune system & have been fortunate to make many important, impactful discoveries, placing me in the top 0.5% of immunology experts. The OpenAI GPT-5 Thinking & Pro models now match or even surpass my expertise in immunology!

This gpt5 model I'm hearing about might be a good model!

GPT-5 just finished Pokémon Red! 6,470 steps vs. 18,184 for o3! Check the stats site to compare! That's a huge improvement! Well done, OpenAI you cooked with GPT-5. What an incredible model. Next up: GPT-5 vs. Pokémon Crystal (16 Badges + Red). The run starts soon on Twitch.

What’s next on the path to AGI? In Episode 5 of the OpenAI Podcast, Chief Scientist Jakub Pachocki and Technical Fellow Szymon Sidor join host Andrew Mayne to explore the journey to AGI so far — from today’s breakthroughs to the possibilities ahead.

1/ XBOW Unleashes GPT-5’s Hidden Hacking Power. OpenAI's initial assessment of GPT-5 showed modest cyber capabilities. But when integrated into the XBOW platform, we saw a completely different story: performance more than doubled. More on what we found: 🧵

i *really* like this version of gpt5 chat and consider it sota for casual conversation it’s still much less sycophantic than 4o, but it’s _kind_ and feels unconditionally there for me in a way the gpt5 chat we shipped sometimes didn’t

Triathlon Part II, Summer 2025

I really recommend trying gpt5-pro ... For research level questions it is in a league of its own imo

I managed to prompt gpt-5-thinking into proving the tight 1.75/L matching v2 of the arxiv paper. From the arxiv paper, it was clear that this problem is perfect for PEP framework. I told gpt to do a search in the coefficients for combining cocoercivity at different pairs of

At OpenAI, we believe that AI can accelerate science and drug discovery. An exciting example is our work with @RetroBiosciences, where a custom model designed improved variants of the Nobel-prize winning Yamanaka proteins. Today we published a closer look at the breakthrough. ⬇️

Ezra Klein on GPT-5:

GPT-5 Plays Pokémon Crystal - Last Update 🔥 Annnnnnd it’s done! GPT-5 beat RED, the final boss, in 9,517 steps vs. 27,040 for o3 - a huge improvement. It went in under-leveled, but the strategy was strong enough to take RED down easily. Well done, OpenAI GPT-5 feels like a

My team forced me to post this. It's definitely the last time I organize a nice offsite for them 😤😂