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What impacts transmission within cities? Knowledge can guide vaccine strategies -> high populated and mobile areas, but also people with more severity. Read more here: medrxiv.org/cgi/content/sh… @MadStange Sarah Brüningk Juliane Klatt Karsten Borgwardt University of Basel UniSpitalBaselCH D-BSSE, ETH Zurich

Our most important #COVID19 work so far: Sarah Brüningk Juliane Klatt & @MadStange examined determinants of SARS-CoV-2 transmission in a city, which could guide vaccination strategies. Spearheaded by AppliedMicrobiologyResearch, w/ H. Hirsch & UniSpitalBaselCH D-BSSE, ETH Zurich medrxiv.org/content/10.110…

#BRCCH warmly welcomes 5 new research projects! Postdocs, together with established Investigators, will conduct translational and ambitious research in #childhealth. Read about the projects👉brc.ch/early-career-r… University of Basel ETH Zurich Swiss TPH 📷J.Pelikan/SwissTPH

It was a great experience talking to the students at St.Joseph's Academy! Thanks a lot to Skype A Scientist for this opportunity! Engineering Students Enjoy Skype with Scientist sjabr.org/student-life/n…

reComBat: batch-effect removal in large-scale multi-source gene-expression data integration. #BatchEffectRemoval #GeneExpression biorxiv.org/content/10.110… bioRxiv Bioinfo

Towards personalized therapy in DMG with #ML by ⁦Sarah Brüningk⁩ Treatment response curves, combining classical mathematical modeling with ML, and interpretability aware model training! ⁦PNOC⁩ ⁦PNOC DMG-ACT⁩ ⁦PNOC Foundation⁩

We review in a new preprint the synergistic combination of knowledge-driven and data-driven modeling in #mathonco with John Metzcar Paul Macklin Catherine Jutzeler-Walter Sarah Brüningk and thanks also to Saskia Haupt Alexander Zeilmann arxiv.org/abs/2312.07026

Interested in ongoing clinical trials in #SpinalCordInjury❓ Check out our SCITrialsFinder.net website🖥️: ✅ Trials carefully curated by experienced investigators ✅ Easy to understand trial summaries ✅ Instant notifications about new trials ✅ Seamless contact to trial locations

Our work on #LongCovid 🩸 is now out in Science Magazine! We found increased complement activation and markers of thromboinflammation in patients with active Long Covid. 1/ doi.org/10.1126/scienc…

The complement system is part of the innate immune response and is unfortunately often forgotten right after the immunology exam. Here’s a recap by Kurzgesagt: 2/ youtu.be/BSypUV6QUNw

We measured >6’500 proteins in the blood of COVID-19 patients during initial infection and 6 months later, compared to healthy controls. 6 months after infection, one protein stood out: complement C7. 3/

Experimental validation revealed that C7 complexes were decreased in the blood of Long Covid patients. Long Covid patients that had recovered before 6-month follow-up, showed normal levels. 4/

Functional assays revealed increased complement activation. Increased C5bC6 serum levels contrasted with the decrease of C7 complexes. This pattern suggested increased incorporation of terminal complement complexes in cell membranes. 5/

Using #MassSpec, we found increased markers of tissue injury, including red blood cells, platelets, and endothelial cells. #FlowCytometry paired with #scRNAseq showed increased monocyte-platelet aggregates in Long Covid patients. 6/

But why is complement activated in the first place? 1) Tissue injury can be caused by, and activate, complement 🔄 2) Cross-talk with a dysregulated coagulation system ↔️ 3) Classical activation mediated by antibodies ⬇️ 7/

By measuring antibodies against >80’000 viral epitopes we found increased IgG against #herpesviruses in Long Covid patients, particularly against CMV and EBV. Anti-CMV was associated with markers of antibody-mediated complement activation. 8/

Altogether, an overly activated complement system may connect different hypotheses on Long Covid pathomechanisms. While the results require further validation in larger patient cohorts, they provide a basis for new diagnostic solutions and possibly targeted treatments. 9/

We are very grateful to all the patients donating blood! Also huge thanks to everybody involved in generating and analyzing all data, including Sarah Brüningk @tebiwankenebi Petter Brodin Adriano Aguzzi Christoph Messner Noam Beckmann Karsten Borgwardt and all members of the Boyman lab. end/