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Our new paper! mRNAs play structural roles in the cytoplasm. The longest mRNAs bound to FXR1 generate an mRNA-protein assembly that plays an essential role in cellular signaling by enabling proximity of proteins without RNA binding domains. cell.com/cell/fulltext/…

I love papers showing that mRNA is more than just code for protein. Congrats Christine Mayr & team

Hello RBP world! We can't wait to meet you all next year! #EMBLRBP

Excited to see out in nature my postdoc work! “Membrane prewetting by #condensates promotes tight junction belt formation” How do #tightjunctions form a belt in #epithelia sealing our body cavities? Alf Honigmann MPI-CBG Dresden Biotechnology Center (BIOTEC) of TU Dresden w/ #Jülicher MPI-PKS Dresden doi.org/10.1038/s41586…

second (for now... 👀)Nature paper of the year I've worked on (and in a completely different topic!) 🥳🥳🥳 Congrats Pombo-GarciaLab !! The paper is exceptional! nature.com/articles/s4158…

The role of biomolecular condensates in protein aggregation nature.com/articles/s4157… A review by Brent Visser, Wojciech Lipiński & Evan Spruijt from SpruijtLab Radboud University @[email protected]

Extremely happy to see our story out in Molecular Cell! doi.org/10.1016/j.molc… We show how Ki-67 & pre-rRNA phase separate, gluing mitotic #chromosomes together! 🧼🧬🧲 @EMBL EMBL Heidelberg Uni Heidelberg ISTAustria Cuylen Lab Andela Saric Ellenberg Lab

So happy to see our work out today on using condensate capillarity to move genomic loci on demand inside live cells! It’s been such a fun project- best part was working with the best team ever 🫶brangwynnelab Amy Strom Hongbo Zhao Oliver Yi-Che Chang Kees Storm Natalia and Andrej!🤩🧬

Check out our latest work on a new function of RNA in transmembrane transport: riboregulation of the mitochondrial import of ATP synthase ATP5A1 biorxiv.org/content/10.110…

Beyond excited to have our paper in J. Am. Chem. Soc. !! We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. malay mondal Tristan Clemons USM Arts & Sciences USM Polymer Science & Engineering pubs.acs.org/doi/10.1021/ja…

New Preprint Alert! 🚨 Check our latest work on #NuMA and #Dynein 🔬 👉 doi.org/10.1101/2024.0… NuMA activates dynein/dynactin via its N-term and caps microtubule minus ends via its C-term, allowing dynein-driven minus end transport, the basis of spindle pole focusing!

Checkout the latest work from the lab online today in Molecular Cell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by Nancy De La Cruz Prashant Pradhan and Reshma T Veettil .

Out today at Nature Communications In collaboration with our awesome UB colleague, Sangwoo Shin, we report how ion gradients control the formation, localization, and transport of biomolecular condensates. nature.com/articles/s4146…

Just arrived in Tokyo & now on the Bullet Train to Sendai, and I saw our latest preprint has just been posted on bioRxiv.😊 In this work, we studied condensate-mediated chaperoning of a pathological amber stop codon prion protein mutant (Y145Stop) biorxiv.org/content/10.110…

Happy to say that my new edition of Thoreau and Arendt On Civil Disobedience ships today! I hope it is not too timely. Or maybe i hope that it is.

1. Excited to share our new study, just published in Cell. First off, link to paper: cell.com/cell/fulltext/…

Great to see our finding of heteromeric amyloid filaments of TDP-43 and annexin A11 in FTLD-TDP Type C now online nature! nature.com/articles/s4158…

🧵 Exciting new findings on bacterial stress response regulation, driven by small proteins (≤50 amino acids). Big shoutout to the amazing team behind this work led by Sangeevan Vellappan (Sangeev). Read the full study here: biorxiv.org/content/10.110…

Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress: nature.com/articles/s4159…