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It was a pleasure to host Prof. Annette Bayer from the Artic University of Norway today, who gave a very inspiring lecture about stereoselective CO2 fixation and beta-lactamase inhibitor design Synbioc Faculty of Bioscience Engineering UGent #CO2

Join us in Turku at #RRB2025 and meet Prof. Bert Weckhuysen BertWeckhuysen Read our latest RRB newsletter Åbo Akademi University @YagutRinne Turun yliopisto - University of Turku Synbioc GREEN-CHEM InBio.be Faculty of Bioscience Engineering UGent mailchi.mp/d431f0580eaf/r…

Congratulations to our new Synbioc doctor Katarina Magdalenic for the excellent work on curcuminoids, and many thanks to Prof. Zrinka Rajic from the University of Zagreb for acting as an external jury member! Katarina Magdalenic

Teambuilding activity at the Christmas market in Ghent 😀 Synbioc Emma Vandenheede Katarina Magdalenic

Season's Greetings and best wishes for a Merry Christmas and a prosperous New Year. May the coming year be filled with success, health, and happiness. Christian Stevens Matthias D'hooghe Sven Mangelinckx T. Heugebaert Green Chemistry Group

Kicking of the new year with our first publication: Our paper dealing with FEM1B-recruiting HDAC #PROTACs is online in #JMedChem ACS Publications Bio & Med Chem Content. We noticed selective HDAC1-3 degradation. Congrats to Felix Felix Feller, Irina, Martina, Heiko, Svenja and Maria! pubs.acs.org/doi/10.1021/ac…

New Paper Alert! See our joint Synbioc - VIB Medical Biotechnology work on #HDAC6 ubiquitin-binding domain inhibitors published in Eur. J. Med. Chem. doi.org/10.1016/j.ejme… Elsevier Chemistry, in collaboration with University of Toronto Rachel Harding, KU Leuven, Centre for Synthetic Biology, Kristof Van Hecke - XStruct. Faculty of Bioscience Engineering UGent

Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators! pubs.acs.org/doi/full/10.10…

New paper! Our work on cancer cell cytotoxic benzothiazepanes (part 3), in collaboration with the Rega Institute KU Leuven, is published in J. Heterocyclic Chem.: dx.doi.org/10.1002/jhet.4… Katarina Magdalenic Synbioc Faculty of Bioscience Engineering UGent Wiley Chemistry #curcumin

Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/ac…

Thrilled to share our #JMedChem paper dealing with DS-103! The ethylhydrazide DS-103 fully reverses cisplatin resistance and binds to HDAC6 in a manner similar to a hydroxamate. Huge congrats to first authors Daniel Daniel Stopper & Lukas and the entire team! pubs.acs.org/doi/10.1021/ac…

Agrochemicals have a global impact by helping feed the world's growing population. But what does an agrochemical 'look like'? Check out the updated 150 Most Recently Disclosed Crop Health Active Ingredients! High-Res PDF: bit.ly/CropHealthPost…

The next chapter of our HDAC #PROTAC story: CRBN-recruiting PROTACs based on a non-selective ethylhydrazide #HDAC warhead induce selective HDAC6 degradation. Congrats to my PhD students Daniel Daniel Stopper & Irina (co-first authors), and Felix Felix Feller. pubs.acs.org/doi/full/10.10…

In vitro and in vivo ADME of heterobifunctional degraders: a tailored approach to optimize DMPK properties of PROTACs© - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/art…

Every year, my students organize ETOC Symposium, a fantastic and free online symposium dealing with research at the cross section of organic chemistry and technology. While I do essentially nothing, I am their biggest supporter! You do not want to miss this great line-up👇

#SynBioC Proud about our SynBioC team who participated at the Sofico Ghent Half Marathon last Sunday! We love: "Work hard, play hard" Christian Stevens Matthias D'hooghe Sven Mangelinckx T. Heugebaert Green Chemistry Group Faculty of Bioscience Engineering UGent

Re-inventing the wheel. Instead of a #ChemEd #Chemistry summary, here is my attempt at a pKa (in H2O) scale. Values are taken from the Evans/Ripin & Hans Reich resources. If you want a table, I recommend these. This was an attempt at a more visual representation of the same data.

Check out our new paper on 3-imino-β-lactam chemistry, published in J Org Chem/Org Lett: pubs.acs.org/doi/full/10.10… Synbioc Christian Stevens Emma Vandenheede Faculty of Bioscience Engineering UGent

Our PhD student Ulrike Ronse presenting a decade of work on HDAC6 in our group at the Medicinal Chemistry Frontiers 2025 conference in Chicago 😀 Synbioc VIB Medical Biotechnology Faculty of Bioscience Engineering UGent EFMC

Our review paper on the synthesis and antibacterial properties of C4-functionalized β-lactams is published in ChemMedChem: doi.org/10.1002/cmdc.2… Synbioc Faculty of Bioscience Engineering UGent Emma Vandenheede Christian Stevens