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Great article about the MRC Laboratory of Molecular Biology scientific culture and organisation nature nature.com/articles/d4158…

CryoDRGN ❄️🐉 has officially joined #TeamTomo! In addition to reconstructing conformational heterogeneity, cryoDRGN-ET was surprisingly efficient at classifying subtomograms!

Pretty cool analysis of the cultural evolution of filled pasta (link.springer.com/article/10.100…). Gotta try them all...

Would you like to work in the MRC-LMB EM facility? mrc.tal.net/vx/mobile-0/ap…

The "ChatGPT moment" for biology proceeds to unfold as Profluent announces proseLM, a new method which incorporates structural and functional context to protein language models for precise and steerable protein design. Ali Madani Jeff Ruffolo 1/ genengnews.com/topics/artific…

Cryo-EM phase-plate images reveal unexpected levels of apparent specimen damage biorxiv.org/cgi/content/sh… #biorxiv_biophys

Can free-living eukaryotes exist without mitochondria? In a new paper from my group led by Shelby, we show that the answer is probably yes! nature.com/articles/s4146…

🔬 We continue our journey through our impact stories. How about a microfluidic device that improves time-resolved cryo-EM developed by Rouslan Efremov and colleagues VIB_StructuralBiologyBrussels to give us a new view on protein interactions? 👉 vibbio.tech/4fr5i2w

Happy to see the L-ENA story make its way to the Nature Communications website. Great collaboration with NMBU Oslo. VIB VUB nature.com/articles/s4146…

Computational design of serine hydrolases Institute for Protein Design 🚀 New preprints from David Baker! 🚀 1. Groundbreaking study uses advanced computational design to create novel serine hydrolases with unprecedented catalytic efficiencies. These new enzymes could revolutionize

How to sense danger from afar? Revised and refined, our paper on the insights into smell recognition by a mammalian trace-amine receptor from Cryo-EM, modelling and functional studies is finally out! nature.com/articles/s4146…

I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is offically out! doi.org/10.1038/s41467…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Mitochondrial ATP synthase dissected in situ! 6 distinct states of the central stalk with 21 substates, some never seen before. Mito structural biology feast! Brilliant work by Lea Dietrich Ahmed-Noor A. Agip Andre Schwarz from Werner Kühlbrandt's lab Max Planck Institute of Biophysics science.org/doi/10.1126/sc…

Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM | Journal of Biological Chemistry jbc.org/article/S0021-…

Building on the work of Richard and Chris, here is our latest work showcasing the potential of the 100 keV #Tundra microscope with the Ceta F and Falcon C. We achieved high-resolution structures for a variety of protein complexes🧵.🔬#100keV #CryoEM. Movie by lingboyu

LinkedIn is now using everyone's content to train their AI tool -- they just auto opted everyone in. I recommend opting out now (AND that orgs put an end to auto opt-in, it's not cool) Opt out steps: Settings and Privacy > Data Privacy > Data for Generative AI Improvement (OFF)

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.110…

What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too? And why should we care? A 🧵 on our paper on the Nobel Laureates. A teaser: the income distribution of the laureates' fathers.1/N