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A study by Gross et al. used deep learning to refine Surviving Sepsis Campaign risk groups. Findings: 1-hour antibiotics saved lives in probable sepsis, but not in low-risk, possible sepsis—hinting at more precise timing targets. 👉 Want more? Try PACU Lit →

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Hydrocortisone remains the go-to for septic shock refractory to fluids and vasopressors, but how do methylprednisolone and fludrocortisone compare? Save this quick-reference pharmacology chart for your next critical care shift. 📚 Full pearl here: pharmacyacute.com/corticosteroid…

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A Phase 1 randomized study by Datta-Mannan et al. compared subcutaneous lebrikizumab delivery via autoinjector vs prefilled syringe. Results: bioequivalent exposure and safety across both devices. 👉 Want more? Try PACU Lit → pharmacyacute.com/paculit/ #PACULit #PharmacyAcute

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In this study by Bismuth et al., continuous ECG monitoring in the ED identified undiagnosed atrial fibrillation (AF) in 3% of patients — most from underserved populations and at high stroke risk. Early screening could prevent future strokes. 👉 Want more? Try PACU Lit →

In this case report by Ilges et al., sulbactam/durlobactam showed target PK attainment in a patient with severe obesity (273 kg, BMI 103) and acute renal failure treated for CRAB bacteremia. Despite prolonged half-life and massive Vd, therapy was successful with no adverse

In this double-blind RCT by Zavvar et al., intranasal ketamine provided comparable pain relief to IV ketamine and IV morphine for bone fractures. No significant differences in efficacy or side effects (p=0.77). 👉 Want more? Try PACU Lit → pharmacyacute.com/paculit/ #PACULit

This study by Augustine et al. found that while pharmacist-led TOC services didn’t lower readmission rates, they were linked to a significant boost in guideline-directed medical therapy at discharge — a key step toward long-term outcomes. 👉 Want more? Try PACU Lit →

This study by Izumi et al. suggests edoxaban may be a reasonable alternative to warfarin in the first 3 months following surgical bioprosthetic valve replacement, with low embolic events and no intracranial hemorrhage reported. 👉 Want more? Try PACU Lit →