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Here they are: Some of our amazing and inspiring #WomenInScience; PhDs and Postdocs Institute for Regenerative Medicine. Let's celebrate your commitment to medical research on #February11 Women in Science Day 💯🧪. University of Zurich UZH Science UZH Graduate Campus #EqualityInScience

Happy to share the latest pre-print from our lab. A single-cell CRISPR based investigation into clonal expansion and early tumorigenesis. biorxiv.org/content/10.110… A great team effort with MoorLab and Stephanie Ellis

Preprint by the Sendoel (Institute for Regenerative Medicine, UZH Science, University of Zurich), MoorLab (D-BSSE, ETH Zurich, ETH Zurich) & Stephanie Ellis (Max Perutz Labs Vienna) labs "In vivo single-cell #CRISPR uncovers distinct #TNF-alpha programs in clonal expansion and #tumorigenesis" bioRxiv bit.ly/3pMhZ35 #cancer

Publication by the Sendoel lab (Institute for Regenerative Medicine, University of Zurich) with first author Umesh Ghoshdastider "Exploring the pan-#cancer landscape of #posttranscriptional regulation" Cell Reports bit.ly/3REmSXl #RNA #Bioinformatics

The dark proteome encoded by more than 7200 annotated sORFs is redefining our understanding of the human genome. Interested in how to detect microproteins? Check out Fabiola's recent review "No country for old methods". sciencedirect.com/science/articl…

Der Signalweg TNF-α steuert die Umwandlung von Epithelzellen in aggressive Tumorzellen. Die Erkenntnis einer UZH-Studie könnte die Früherkennung und Behandlung von Haut-, Speiseröhren-, Blasen- oder Dickdarmkrebs verbessern: news.uzh.ch/de/articles/me… Sendoel Lab Institute for Regenerative Medicine

The signaling pathway TNF-α drives the transformation of epithelial cells into aggressive tumor cells. This finding of a UZH study could help to improve early detection and treatment of cancers in skin, esophagus, bladder or colon: news.uzh.ch/en/articles/me… Sendoel Lab Institute for Regenerative Medicine

Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…

Thank you Cancer Discovery for highlighting our recent paper. TNF Pathway Alterations Mediate Clonal Expansion and Tumorigenesis aacrjournals.org/cdnews/news/16…

It’s the end of an era as we bid a bittersweet farewell to Peter F. Renz, one of the first members of our lab. Your commitment, spirit and enthusiasm have profoundly shaped our lab’s culture and have not only pushed scientific frontiers but also filled our days with lots of fun..

It was an honor and a pleasure to make a small contribution to help this lab grow. I'm sure the future is very bright for the Sendoel Lab.

Congratulations to Peter (Peter F. Renz) for being awarded the Skin Cancer Award 2024! Well deserved, we are very proud of you!

I was happy to contribute a small part to this very innovative work on single-cell translatomic changes in the aging epidermis led by the incredibly talented Clara Duré . Check it out

Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis biorxiv.org/cgi/content/sh… #biorxiv_cancer

interesting approach to look at clonal dynamics in cancer emergence. Particualrly impressed by the adoption of the Drake equation for cancer.

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function. 1/9 biorxiv.org/content/10.110…

Spearheaded by the very talented Fabiola Valdivia Francia and another great collaboration with the Ellis lab, we used ribosome profiling to map microproteins in healthy epidermis and cancer, annotating more than 3000 novel ORFs. 2/9

Fascinating work by Fabiola Valdivia Francia and Sendoel Lab about the secret roles of microproteins