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Reminds me of bimpson: youtu.be/LfwJJ6s66GE

I think I've developed a good nose for spiritual bypassing. It smells like trying to will a fantasy world into existence by believing something hard enough

we are 10 years from this

existential depression as sense of forshortened future -> rooted in repeatedly thwarted plans and uncertainty growing up -> implied (absence of) parental support and guidance as scaffolding for developing planning and sense of future

Can we please get an "old" feed. The ancient content on Twitter is at least as good as the new

"We have no idea what the data center is doing, but it might be important so let's just leave it alone." The future will be fun.

Realization of the week: I really like to make things pretty. I'm learning to do the ugly thing long enough to discover a prettier alternative. Inspiration is balanced by grit?

Deep meditation isn't fight club. There isn't some great secret no one talks about. If you're treating it like fight club, you're probably running away from something. It does alter your mind so please do it from a healthy place :) <Endrant>

On some days, it just seems crazy to me that this is even happening. Just put the phone down! Host a dinner party! Take an in-person class! It’s not that hard

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with Martin Pacesa, Zhidian Zhang , Bruno E. Correia, and Sergey Ovchinnikov. 🧬 Code will be released in a couple weeks

Things that won’t actually make you happy: 1. Making more money 2. Getting more power 3. Becoming a better person 4. Getting the relationship you think you want 5. Having people like you 6. More followers Things that will make you happy: Understanding yourself

Bay Area I have returned

this is still my favorite meme of all time

I hope my work helps people heal and get more quality time with their loved ones

What could scaling unlock for biology? Introducing ProGen3- our next AI foundation models for protein generation. We develop compute-optimal scaling laws up to 46B parameters on 1.5T tokens with real evidence in the wet lab. +we solve a new set of challenges for drug discovery

Lately I'm getting out of my own way by realizing you can feel like shit and still be in a flow state. Then there are lots of options beyond trying to feel better. (And sometimes trying to feel better is the right option)

I wish I did more with my Saturdays

When it feels like everything sucks, there's actually something that sucks and a lot of resistance or confusion. If you can't find a single thing that is okay, the not okay thing probably needs a fresh perspective. Finding an okay thing isn't ignoring, it's grounding.

Take 3 deep breaths. Then ask yourself from wonder: Who are you when there is nothing left to improve?