Twitter Beğeni Hilesi

The first genome sequence of a human cancer was reported 15 years ago. As Sheng Cai & Ross Levine discuss, this ushered in a new era of diagnostic, prognostic and therapeutic advances. go.nature.com/40TFhlD

Too cool!!! Wowza

Our paper is out today in nature! Imagine getting this plot when studying single-cell data of growing bacteria! Could it be the cell cycle?! We found that a gene’s response to its replication reveals gene regulation on a genomic scale. nature.com/articles/s4158… Andrew Pountain

Congratulations to Eleonore Toufektchan and all co-authors on our new study showing how TREX1 guards against anti tumor immunity by degrading cytosolic DNA to limit cGAS-STING! Great collaboration with the Samuel Bakhoum lab.

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

Odličan primjer su prilike naše mlade znanstvenice Mije Petljak Mia Petljak koja je nedavno otvorila svoj lab na NYU Grossman Medical School i traži postdoktoranda, senior znanstvenika, i čak remote interne iz područja bionformatike! #internships #postdocs #jobopportunity

Now online! APOBEC3A and APOBEC3B drive distinct mutational landscapes in tumors. We showed how A3A and A3B substrate preferences for different hairpin structures can be exploited to identify patients' tumors with mutations caused by either A3A or A3B. nature.com/articles/s4146…

Children who develop two independent tumors during childhood are extremely rare. We wanted to shed light into those exceptional cases using genome analysis We also reveal the mutational footprint of chemotherapy in normal tissues using duplex sequencing of autopsy samples 👇

Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! biorxiv.org/content/10.110…

Interested in learning more about the many functions of Reactive Oxygen Species in cancer? Check out our recent review in Nature Cancer. Special thanks to Kat who in collaboration with Ahmed and Sayin Lab - UGot put together this comprehensive review article nature.com/articles/s4301…

Big news, Nowosad Lab is hiring a technician! Come and help us figure out how B cells tell friend from foe in the intestine. You can message me, check out our lab website, or apply here > jobs.nyulangone.org/job/20205972/r…

Pop it in your diary for next week!

I am thrilled that our paper on kidney cancer is now out in nature!!! nature.com/articles/s4158…

From a single member in Aug 2023 to this powerhouse squad! 🚀 💕#BestTeam

Clustered mutations occur more frequently than expected, and translesion synthesis (TLS) drives collateral mutagenesis on both the leading and lagging strands. SNVs are clustered downstream of deletions (biased towards deletion of T) but upstream of insertions. [4/13]

Now out nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)! go.nature.com/3KG7Njh

Paper out!📢 Anupriya Singhal and #HannahStyers from the lab find acute resistance to targeting KRAS in pancreas cancer is surprisingly driven by a classical epithelial state. Co-targeting classical cells and KRAS augments response - clinically important! aacrjournals.org/cancerdiscover…

Wow!

Excited to see Ben Ebert as the new CEO at DFCI! His brilliance is matched only by his compassion and humanity. Ben’s been a fantastic collaborator and advisor to so many of us. Looking forward to witnessing all that’s ahead under his leadership.