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This is a case of Eosinophilic Solid and Cystic Renal Cell Carcinoma, with typical lower-power solid and cystic areas. Large eosinophilic tumor cells are characteristic. #surgpath #pathtwitter #pathology #pathologists #genitourinary #kidney

Look out - it's the myxoid, MUC4-positive variant of superficial CD34-positive fibroblastic tumor (PRDM10-rearranged soft tissue tumor) #BSTpath

A common finding in salivary glands, particularly in the parotid : sebaceous glands

when the #GUpath prostate bx looks like solar elastosis, think about some prior ablative therapy (here: HIFU) #beautyinb9

Next-Generation IHC strikes again! Hot new stain alert. This patient had about a dozen small NETs involving the pancreas & duodenum. The duodenal NETs were gastrinomas. What's the identity of this tumor suppressor?

Thank you for playing. This, my friends, is a non-cutaneous syncytial myoepithelioma of bone. Wouldn't have recognized it if it weren't for Greg Charville and his excellent post: x.com/Greg_Charville… Here is a paper he and colleagues came up with: pubmed.ncbi.nlm.nih.gov/37548750/

Polymorphous adenocarcinoma 📕Salivary💧gland malignancy 1️⃣site: Palate 🩺 Slow growing, painless mass 📈Avg Age: 70s 🎨CK7, S100+ 👍 10 yr survival: 94-99% 🧐Monomorphic cells but "Polymorphous" architecture 📖Conventional+cribriform subtype 🧬PRKD1

Teen, >15cm retroperitoneal mass with bone invasion. #BSTpath

Frozen section pitfall #GUpath When analysing a surgical margin of the ureter, don't forget to closely look at all layers including the adventitia. Plasmacytoid urothelial carcinoma depicted here :

Prostate cancer invading into fat in trans-urethral resections of the prostate (TURP) does NOT necessarily = extra-prostatic extension- see below 👇👇 Grateful to be included in this work Ankur Sangoi @stanfordpath #GUpath #PathTwitter

70s F 2cm subQ mass. Dx? #PathX #PathTwitter #BSTpath

Salivary ___ carcinoma is defined by rearrangements of ETV6 A) secretory B) acinic cell C) duct #PathTwitter #Pathology #ENTPath #PediPath

Urinary bladder, leiomyosarcoma #gupath #GUpath

Adrenal cortical carcinoma #GUpath #gupath

Ana-Maria Catana Miruna Popescu, MD x.com/williamson_sr/…

I bet my bottom dollar you do not know this! 🔴 S100 protein is expressed by ampullary neuroendocrine tumors ➡️ And pancreatic neuroendocrine tumors ➡️Far less commonly than other neuroendocrine tumors ➡️Could be used to predict site of origin bit.ly/4ccgCgA

Hepatic Epstein-Barr virus-associated smooth muscle tumor. This lesion arose in a man with HIV disease and multiple other medical problems. Desmin, CD117, and DOG1 were negative. #umiamipath PMIDs:36965331, 16330945.

This is a lung adenocarcinoma from a non-smoking woman. What is the most likely molecular alteration? #nsclc #drivergenes

Highlighting #prostatecancer w/poorly formed glands - this pattern 4 manifestation is often challenging due to the need to exclude tangential sectioning (examine multiple levels) & in small foci (issues with assigning % pattern 4) #gupath #ProstateCancerAwarenessMonth

Going beyond canonical MYB::NFIB and MYBL1::NFIB gene fusions ins adenoid cystic carcinoma #entpath #pathology Discovery of Novel TULP4/ACTN4/EWSR1/ACTB::MYB and... : The American Journal of Surgical Pathology journals.lww.com/ajsp/fulltext/…