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What a pleasant surprise😃!!Our structure has made it to the cover of RNA. Thanks a lot for highlighting our #RNA work from Mahavir Singh Molecular Biophysics Unit, IISc IISc Bangalore!! rnajournal.cshlp.org/content/29/3.c…

Glad to be a part of this work from Ashok's team at the IISc Bangalore! Structure and DNA binding mechanism of an excited fully folded conformation sampled by an IDP! Madhurima Kulkarni IIT Madras Department of Biotechnology IIT Madras Molecular Biophysics Unit, IISc science.org/doi/10.1126/sc…

First instance of unfolded to folded ensemble equilibrium demonstrated with exquisite #NMR #CEST experiments and parameters #ChemicalShifts #RDCs by #AshokSekhar and co-workers. A must read!! #IDP #DNA #ProteinDNA Comprehensive work!! Congrats!! Madhurima Kulkarni Athi N Naganathan

Do read our work on multi-pronged approach (structure survey, #NMR measurements and #MD) that unravels "Conformational Plasticity of Parallel #GQuadruplex - Implications on #DuplexQuadruplex Motifs"🧬 pubs.acs.org/doi/10.1021/ja… Rajesh Sannapureddi Manish Kumar Mohanty #LoicSalmon Dept of Chemistry, IISER Bhopal

🎁HBT #chemistry #NobelLaureate 1990 E. J. Corey turning 95 today. PhD with J. C. Sheehan @MITin 1951; faculty member University of Illinois, full professor at age 27. In 1959 he moved to Harvard Chemistry where he has been ever since, still active prof. em. He educated over 700 group members,

Check out this protocol for the purification of bacterial type III toxin-antitoxin RNA-protein complexes from E. coli for biophysical studies from our lab Molecular Biophysics Unit, IISc IISc Bangalore Manikandan Kavyashree Nadig Bio-protocol

Researchers at Brown University and Dalgarno Scientific LLC have developed an innovative method using AlphaFold 2 to predict relative populations of protein conformations without needing a physics engine. AlphaFold 2, already renowned for its accurate protein structure

Remembering the legacy of Prof. G.N. Ramachandran Molecular Biophysics Unit, IISc IISC

For nearly a decade I've wanted to write a profile of this remarkable woman. Thank you, @tvjrennie and Quanta Magazine, for giving me the space and time to do it. quantamagazine.org/in-our-cellula…

As a PhD student or academic, you have a lot on your plate.  But getting shit done doesn't have to be overwhelming.  Here are some methods that will help you stay focused and productive: Thread 🧵

Biomolecular NMR Post-Doctoral Positions in Lewis Kay Lab Kay Lab University of Toronto pound.med.utoronto.ca #NMRjobs #NMRchat #NMR

Researchers at IISc have identified a potent protein from Budgett’s Frog that can combat disease-causing agents by inhibiting its key enzymes. The finding provides a template to engineer more specific inhibitor proteins. iisc.ac.in/frog-skin-pept… #IIScresearch

youtube.com/watch?v=07JtMV… Dr. Kevin Gardner and Dr. Ruth Stark received a National Institute of Health (NIH) grant to build a helium recycler for the City College of New York and the CUNY Advanced Science Research Center (ASRC) at CCNY. Why is this important? -

Newest paper from the lab is now out in PNASNews! Alex (Alexander Sever), Reid (Reid Alderson) & others provide mechanistic insights about the mechanism of Caspase-9 activation on the apoptosome. Check it out here: pnas.org/doi/10.1073/pn…

For anybody interested in the conformational dynamics and interactions of intrinsically disordered proteins may want to check our recent short review in COSB sciencedirect.com/science/articl…

We are delighted to announce the second Featured Speaker of the TNQ Distinguished Lectures in the Life Sciences – 2024: John Jumper, who currently leads the revolutionary AI-driven #AlphaFold project at Google DeepMind. See details and register online: tnq.co.in/johnjumper/

Happy to share our recent work on the metamorphic protein, Mad2. We have established the role of sparsely and transiently populated conformations of Mad2 in metamorphosis as well as function. Molecular Biophysics Unit, IISc onlinelibrary.wiley.com/doi/full/10.10…

Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR | Journal of the American Chemical Society Molecular Biophysics Unit, IISc #HydroxylExchange #Glycans #NMR Magnetic Resonance News pubs.acs.org/doi/10.1021/ja…

Looks interesting: "A Functional Map of the Human Intrinsically Disordered Proteome" 🍝 by Iva Pritišanac, Reid Alderson, Đesika Kolarić, ..., Julie Forman-Kay, Moses Lab doi.org/10.1101/2024.0…