Twitter Beğeni Hilesi

1 month=76 patients included!😮 This setup is a logistic challenge but it works!! All the ambulance staff in Region Hovedstaden and Region Sjælland, and the doctors at Rigshospitalet are doing an amazing job including patients every day! We have now included 19% of the patients! 🫀 👏

Does prehospital administration of pulse-dose methylprednisone reduce final infarct size in #STEMIpatients? The #RCT have been running for almost 2 months and we have included 155 patients. Now, the first patients are being called in for the 3-months follow-up #CMR🫀RigsHeart 🫀🚨

After just 3 months, 214 patients have been included in the PULSE-MI trial! Today, the fifth patient will undergo the 3 month follow-up CMR to evaluate final infarct size 🫀 @rigsheart #RCT

50 patients (12%) have now completed the 3-months #CMR. A total of 211 patients with #STEMI have now been included in just 4 months!! 🫀 The trial is powered to find a 20% reduction in final infarct size -> 378 3-months #CMR are needed! RigsHeart 🫀🚨 Jasmine Melissa Madsen Laust Obling #RCT

#Thread 1/4 Can early anti-inflammatory #steroid treatment in the pre-hospital setting of a resuscitated #OHCA mitigate the progression of post-cardiac arrest syndrome? 😵🫀 The #STEROHCA trail chaired at Rigshospitalet is about to reveal its results! #CardioTwitter

WHAT A #MILESTONE!! After JUST 11 months - today the last patient was randomized in the PULSE-MI trial! 🫀🚑 The last FU will be completed in January 2024! ✅ We are excited to share the results on the trial in the beginning of 2024! 🫀 #CardioTwitter #RCT RigsHeart 🫀🚨

Now Laust Obling presenting the results of the #STEROHCA RCT: STERoid for OHCA patients #LIVES2023

🧠 Early methylprednisolone in comatose #OHCA patients: may improve outcome?? STEROHCA 🇩🇰 RCT 🚑 prehospital single high-dose IV (250 mg) vs placebo resulted in 💉substantial decrease in IL-6 after 24h 💉no effect on NSE levels during first 72h #FOAMcc 🔓 rdcu.be/dqJU7

Our review on the neuroinflammatory cascade of post #cardiacarrest brain injury. Neuroinflammation likely has distinct pathways than the systemic cascade following resuscitation. Laust Obling Adam Thomas physoc.onlinelibrary.wiley.com/doi/abs/10.111…

🔥Giving steroids after #OHCA? Pathophysiology of post-CA syndrome features I/R injury & release of high levels of inflammatory cytokines. It would make sense to provide anti-inflammatory agents early after ROSC 🔓rdcu.be/drREl On STEROHCA RCT 🔓rdcu.be/dqJU7

🚑 Exciting STEROHCA results! 📊 Prehospital high-dose glucocorticoid treatment significantly reduces norepinephrine use in comatose OHCA patients (p = 0.02). 📈 Additionally, the glucocorticoid group exhibited higher MAP and lower VIS/MAP ratio. Link: rdcu.be/dwGzR

🧠 Early methylprednisolone in comatose #OHCA patients: may improve outcome?? STEROHCA RCT on 🚑 prehospital single high-dose IV (250 mg) vs placebo Full results #FOAMcc on Intensive Care Medicine 🔓 rdcu.be/dqJU7 Editorial 🔓rdcu.be/drREl ⬇️ Below visual abstract

TOP, MUST-READ CARDIAC ARREST TRIALS OF 2023 🫀⚡️ We summarized in this infographic 4 important multi-center RCTs published in 2023 in the fields of cardiac arrest and CPR Concomitantly published with a concise review in Resuscitation 🔗 sciencedirect.com/science/articl… 🧵1/4 #FOAMcc

Steroid Therapy After Cardiac Arrest? Learn more next week... Laust Obling MD Copenhagen, Denmark Prehospital steroids in patients resuscitated from out-of-hospital cardiac arrest:  STEROHCA trial bit.ly/sterohca MUV- Monash - UW Resuscitation Rounds Weds, Apr 3,

In the subgroup of patients with heart failure from a trial of blood pressure targets after cardiac arrest, higher targets increased heart rate but did not alter cardiac index or mortality Johannes Grand RigsHeart 🫀🚨 Laust Obling Jakob Josiassen #AHAJournals ahajrnls.org/3RwdK6m

🚨 PhD defence 🚨 Dr. Laust Obling is defending his PhD thesis “Steroid as anti-inflammatory and neuroprotective agent following resuscitated out-of-hospital cardiac arrest -STEROHCA - a randomized trial" Time: 12 Aug. 2024, 14:00 Place: Panum, Henrik Dam aud, 7.15.92 Christian Hassager

Pupillometry after #OHCA, substudy of BOX trial 👁️ thresholds of pupillary light reflex < 4% & Neurological Pupil index ≤ 2 predict unfavorable neurological outcomes, 0% FPR 👁️ combined with NSE > 60 μg/L ⬆️ its sensitivity without ⬆️ false positives 🔓 rdcu.be/dRGr7