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I have always been fascinated by the CTCF convergent rule. How can a large (~50 nm) extruding cohesin complex distinguish whether it approaches a comparatively tiny (~3-5 nm) CTCF protein from the left or the right? So, I reviewed recent studies on this: tandfonline.com/doi/full/10.10…

New paper: DNA capture by a CRISPR-Cas9–guided adenine base editor science.sciencemag.org/content/369/65… Great collaboration with Gavin Knott @enrique_lins David R. Liu Peter Beal @doudna_lab

With cryoEM, UC Berkeley scientists capture CRISPR-Cas9 base editor in action news.berkeley.edu/2020/07/30/new… via @igisci

Join us for this event: RNA at the Bench and Bedside II cvent.me/OKnavO?sms=2 #RNABench2Bedside

Aaron Feller joins the lab! lapinaitelab.org/news

Kayla Perry Kayla Perry, Ph.D. joins the lab! 🥳 lapinaitelab.org/news

Are you interested in our research? Here is one of the ways to join :)

Our brand new incubator fits like a glove!

Kicking off the 2023 ⁦Cold Spring Harbor Laboratory⁩ #CryoEM course! Participants have braved flight delays, train fires, and long immigration lines to be here, looking forward to the next 2 weeks!

Day 2 of the 2023 Cold Spring Harbor Laboratory Cryo-EM Course! Honored to be attending for the next 2 weeks! Cold Spring Harbor Laboratory CSHL Courses #CryoEM

So proud of my student Kayla Perry, Ph.D. who received Marie Curie Best Use of Chemistry poster award! Congratulations!!! Biodesign Institute at Arizona State University ASU School of Molecular Sciences LapinaiteLab

Congratulations to our undergraduate, Marisa Bennett, for passing her Barret Honors College Thesis Defense today!! 🎉🎊 Barrett, The Honors College at ASU

A (1 day late) birthday celebration for our Ph.D candidate Madeleine King! 🎉🎈🎊🎁🎂 Madeleine King

Join us this Friday at 11:00 for a Special Seminar by Prof. Teresa Carlomagno from University of Birmingham, "Why NMR? An integrative structural biology approach to understand functional mechanisms in biological complexes" in Biodesign Auditorium or zoom: asu.zoom.us/j/89520908985

Super excited about the upcoming talk of Teresa Carlomagno Carlomagno Group UoB 🧪🧬

Proud of Xiaoyu and Mitchell, graduate students from my lab, for composing our lab’s first review article. The paper covers the molecular mechanisms of DNA Adenine Base Editors and highlights the remaining open questions. ASU School of Molecular Sciences Biodesign Institute at Arizona State University portlandpress.com/biochemsoctran…

I'm thrilled to share that I've had the incredible opportunity to write with Audrey Lapinaite on a groundbreaking paper about mined novel ribozymes, known as HYERs, capable of DNA cleavage! Read about it more here: nature.com/articles/s4158…