#IDtwitter #Medtwitter I find it difficult to justify the use of oxacillin/Nafcillin over Cefazolin for treatment for MSSA. especially if the patient has heart failure. We are rarely cognizant of how much Salt we give with abxs. Please keep this in mind academic.oup.com/ofid/article/6…

🔥🔥New in Clinical Infectious Diseases: a look at strategies for management of Carbapenem-resistant Acinetobacter baumanii-calcoaceticus complex (CRAB) infections 🦀 #idtwitter

Watch Covid come in at the end and absolutely destroy medical literature for a generation

When your ID doctors remember it’s #IDPharmacistsDay 🥰

🔥BREAKING🔥 US FDA approved Xacduro (sulbactam durlobactam for injection), a new treatment for hospital-acquired bacterial pneumonia &ventilator-associated bacterial pneumonia caused by Acinetobacter baumannii-calcoaceticus complex #IDTwitter fda.gov/news-events/pr…

🚨 Nirmatrelvir/ritonavir (Paxlovid) now approved by FDA as oral antiviral for tx of mild-to-moderate COVID-19. Per ASPR on 5/25/23: Plan to continue distributing EUA-labeled Paxlovid. Sufficient US supply remains & will still be no cost to pts for now. fda.gov/news-events/pr…

I'll be on a Twitter break unless a 🔥 article is published 😊 🌟Top ID news this week 🌟 FDA approved: Paxlovid for COVID-19 Xacduro (sulbactam/durlobactam) HAP/VAP ACB 🌟RCTs🌟 NIH ACTIV-4a PICASSO ATTACK SAFA 🌟Guidelines🌟 AASLD/IDSA Hep C IWGDF/IDSA DFI Happ weeken🆔

🆕️⚡️🔥 #JAC Jesus Rodriguez Baño et Al Effectiveness of fosfomycin trometamol as "oral step-down" therapy for bacteraemic UTI due to MDR E coli :a post hoc analysis of FOREST RCT Brad Spellberg Todd C. Lee No difference in CMC* Higher rate of relapses in fosfo 🤔 academic.oup.com/jac/article-ab…

I guess I just toss these? 🥲 #idtwitter

Todd C. Lee Maybe Piperacillin tazobactam ⬆️ mortality in MSSA Bacteremia x.com/ABsteward/stat…

Options for giving antiretrovirals to persons with swallowing difficulties or requiring tube feeding: 1️⃣Give liquid formulations 2️⃣Crush the tablets 3️⃣Open the capsules Here's a handy reference from EACS guideline

🆕️⚡️⚡️👌 Review article Antibiotics MDPI Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations #IDXposts mdpi.com/2079-6382/12/8…

Comparing the risk for community-associated Clostridioides difficile infection across different antibiotics As expected, clindamycin is the worst 👎 While doxycycline is among those with the lowest risk 👍 doi.org/10.1093/ofid/o…

🔥🔥 Just published 🔥 🔥 The most anticipated guidelines ESCMID guidelines on diagnosis and treatment of brain abscess in children and adults #IDXposts clinicalmicrobiologyandinfection.com/article/S1198-…

📣This week in Infection Control & Hospital Epidemiology : pharmacist-driven MRSA nasal swab + 72-hour restriction protocols decreased vancomycin DOT/1000 patient days, and resistant gram positive SAAR! 🤩cambridge.org/core/journals/… #IDTwitter

🔥Prospective observational study of a 12 years’ national cohort🔥 Cefazolin is a valuable option for the treatment of MSSA IE, without differences in one-year mortality or relapses compared with cloxacillin & might be considered equally effective #IEwiki ijidonline.com/article/S1201-…

🆕️🔥Retrospective multicentre cohort study of PJI Exclusive oral antibiotic therapy or with ≤3 d of IV Abx for 6 weeks was associated with a similar rate of management failure after surgery ompared with other antibiotic therapy options Brad Spellberg academic.oup.com/jac/article/do…

The most anticipated RCT in ID 🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia N:1341 Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia Cefazolin is non-inferior (90d mortality)& less AKI than ASPs A practice-changer RCT that must change the guidelines #ESCMIDGlobal

Ditch the fluoroquinolones, pick oral beta-lactams💊 for uncomplicated gram-neg bacteremia🦠 🔗: doi.org/10.1002/jhm.70… ✍️: Michael Dore #bacteremia #antibiotics #JHM #AntibioticStewardship