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A lot of great talks this year at the APSA JointMeeting ! Looking forward to next year already. UChicago MSTP

Check out our latest work uncovering another connection between glycolysis and the KEAP1-NRF2 pathway. A novel PTM of a KEAP1 cysteine by a reactive glycolytic metabolite. Thanks to coauthors: Lara Ibrahim Kayla Nutsch, PhD Caroline Stanton @LabWiseman pnas.org/doi/10.1073/pn…

He went 166-0 in high school. He was the top recruit for the most successful NCAA program. He was also addicted to opioids. Chance Marsteller went to jail and rehab (twice) and almost lost his wife and kids. Then he beat the best wrestler in U.S. history. olympics.nbcsports.com/2023/06/21/cha…

Anyone that has seen our work knows we have a different view on PTMs! Here, Marissa and I opine that glycation is actually crucial for normal cell health and homeostasis and not simply a marker of sugar overload. Thanks to Nature Chemical Biology and reviewers! nature.com/articles/s4158…

Excited to share our group's most recent work out today in Cell Reports: In this paper, we discover ERK1/2 are regulated by dynamic lipidation - illuminating a new layer of control for these critical cellular kinases cell.com/cell-reports/f… 1/n

Stevan Micic is a 57kg WORLD CHAMPION! 🇷🇸 He upended an Olympic Champ and TWO World Champs en route to winning Serbia’s FIRST WORLD GOLD MEDAL EVER in front of the home crowd… Incredible! He sure earned it. So happy to see him seize a great opportunity, he is a national hero

Our preprint is out! We hacked the Oxford Nanopore sequencer to read amino acids and PTMs along protein strands. This opens up the possibility for barcode sequencing at the protein level for highly multiplexed assays, PTM monitoring, and protein identification! biorxiv.org/content/10.110…

New research from John Coukos Raymond Moellering & UChicago Chemistry colleagues reports the stereospecific conversion of methylglyoxal to l-lactate by #Parkinsons-associated DJ-1 in solution with negligible or no contribution of direct protein deglycation pubs.acs.org/doi/10.1021/ac…

The Moellering Lab has published research in Biochemistry that provides "definitive evidence that recombinant DJ-1 produced in human cells prevents the stable glycation of other proteins through the conversion of methylglyoxal" #Parkinsons Read - pubs.acs.org/doi/10.1021/ac…

Hello!! I have multiple positions open at UChicagoCancerCenter and UChicago Biological Sciences Metabolomics Platform. We have multiple brand new high-resolution #orbitrap #LCMS systems and very exciting #metabolomics projects. This will be a great opportunity to acquire expertise in #LCMS.

In a major milestone for science, for medicine, and for patients, the world’s first CRISPR drug has been approved in the UK. “A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory

Two 2023 studies point toward the #parkinson associated protein PARK7 / DJ-1 as being a glyoxalase, not a deglycase, by acting on the precursor metabolite methylglyoxal: pubs.acs.org/doi/10.1021/ac… pubs.acs.org/doi/10.1021/ac… #PTM #glycation #AGEs

Delighted to share that I’ve been promoted to full Professor The University of Chicago UChicago Chemistry! More than anything this is a reflection of the talent and dedication of my students & postdocs, past and present, alongside support from many mentors, collaborators and the chembio community!

A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Very exciting finding from Ashok Venkitaraman's lab! sciencedirect.com/science/articl…

Key genes and convergent pathogenic mechanisms in Parkinson disease — a Review by Robert Coukos & Dimitri Krainc go.nature.com/4aZ2SoT

In the latest issue! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 dlvr.it/T65TXJ

Excited to share our Nature Chemical Biology publication! Our proximity-triggered protein trans-splicing technology enables precise, time-resolved activation of diverse proteins by manipulating control elements (1/5) nature.com/articles/s4158…

Cool covalent photoacoutstic imaging probes from the Chang lab Emory Al-Imam. #proudofalumni onlinelibrary.wiley.com/doi/10.1002/an…

Today in @natchembio we share a new strategy to design fully synthetic “artificial” bZIP family transcription factors that directly block DNA binding of HIF1a and XBP1 to inhibit hypoxia-dependent oncogenic signaling in cells and in vivo. 1/n  nature.com/articles/s4158…

Kudos to Wendy Luo (MS4) and team (Sarah Mae Lammert John Coukos Parth K. Modi, Tatjana Antic, and Mike Kwon) on their publication on organ-confined prostate cancer with negative margins pubmed.ncbi.nlm.nih.gov/39576420/