Twitter Beğeni Hilesi

Having watched closely through the development of this story for over 30 years, this is a marvelous day. Congrats to my mentor and friend, Stu Orkin, who discovered the mechanism of hemoglobin switching and pointed to the place to target.

Don’t miss this excerpt from the 2023 AACR #CancerProgressReport in Cancer Discovery with summary figures of the most common and most deadly cancer types in the US.

Jian Xu, PhD, Member of the Center of Excellence for Leukemia Studies in the Department of Pathology at St. Jude, talks "Understanding and targeting the non-coding regulatory genome," in The Science of Childhood Cancer lecture series on 2/15/24. Register: bit.ly/3UnuWNI

Congratulations to HMS physician-scientist Stuart Orkin, who has been named to TIME’s 2024 list of the 100 most influential people in the world! Orkin’s research has led to the first gene therapy using CRISPR to treat sickle cell disease. #TIME100 time.com/6964969/stuart…

A Welcome to the Era of Genome Editing today NEJM Overview George Q Daley nejm.org/doi/full/10.10… Casgevy for Sickle-Cell Disease nejm.org/doi/full/10.10… Casgevy for Beta-Thalassemia nejm.org/doi/full/10.10…

Of 30 patients with severe #SickleCellDisease who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from vaso-occlusive crises for at least 12 consecutive months. Read the full CLIMB SCD-121 study results: nej.md/3UvzPDT

Happy to share that our work on how small set of motifs and rules explain most human promoters is published in Science Magazine I am very grateful for the chance to be part of a team of amazing scientists: Donghong Cai, Chenlai Shi,Jian Xu,Jian Zhou science.org/doi/10.1126/sc…

A small set of rules explain transcription initiation of promoters: science.org/doi/10.1126/sc… Congratulations to Kseniia Dudnyk Donghong St. Jude Research & Chenlai. It has been inspiring to work with Jian Zhou UT Southwestern Medical Center. Looking forward to making more discoveries together!

Humans couldn't understand how promoters initiated DNA transcription. Then humans + #AI figured it out. science.org/doi/epdf/10.11… science.org/doi/10.1126/sc… Science Magazine Kseniia Dudnyk Jian Zhou Jian Xu Vikram Agarwal (@vagar.bsky.social)

A study Kseniia Dudnyk Jian Zhou + al Science Magazine developed an explainable machine learning model called Puffin to determine how transcription initiation depends on sequence revealing a small set of motifs and rules that explain most human promoters bit.ly/adj0116

A machine learning model reveals a small set of motifs and rules that explain most human promoters. These findings present a unified model for transcription initiation. Kseniia Dudnyk Jian Zhou Jian Xu science.org/doi/10.1126/sc…

The #ShawPrize in #LifeScienceandMedicine 2024 is awarded to Swee Lay Thein & Stuart Orkin for their discovery of the genetic and molecular mechanisms underlying the fetal-to-adult hemoglobin switch. Congratulations to both laureates! NIH NIH NHLBI Harvard Medical School

Congratulations to HHMI Investigator Stuart Orkin & NIH Senior Investigator Swee Lay Thein the recipients of the 2024 The Shaw Prize in Life Science & Medicine! Their discoveries pave the way for a genome-editing therapy for sickle cell anemia & β thalassemia: hhmi.news/4dMGmSe

Congrats Michael Lee MLeeJr for defending his PhD thesis UT Southwestern Medical Center Children’s Research Institute at UT Southwestern UT Southwestern MSTP. Michael gave an amazing talk on how LINE1 elements regulate genome architecture in cancer. It was a joy to mentor Michael with Jian Xu. -RJD

New! Online now: Electron transport chain inhibition increases cellular dependence on purine transport and salvage dlvr.it/T8Dmtc

Explore the Science of Childhood Cancer lecture archive hosted by the St. Jude Comprehensive Cancer Center to discover a wide array of topics and valuable insights into the latest advancements at the forefront of pediatric cancer research. ow.ly/Ewa150Siq0P

A huge #ASHKudos to the 2024 ASH Honorific Award recipients! This year’s recipients are a group of pioneering scientists, innovative clinicians, and selfless mentors who have advanced hematology through vital contributions! ow.ly/cSrS50SkT9y #ASHAwards #ASH24 #hematology

The power of non-coding alterations in cancer genomics! Congratulations to Petri Pölönen Charles Mullighan and team for this landmark study.