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#NETs in LA ⭐️🎥🌴 Reminder to debulk NETs liver metastases by Alexandra Gangi, MD 🤩 ➡️ mortality in NETs happens in the liver - treat it ⛔️ No to anatomic resection! 👉🏻 enucleate!

PRRT before surgery in #NETs? ☢️🦓 Maybe? 💭 Think about why, how to measure success, potential risks 🤔 Some key reasons to consider the approach by Jess Maxwell MD MBA 👇🏻

Important prospective data on NECarcinoma & G3-NET from NORDIC NEC2 🇩🇰🇳🇴🇸🇪 With chemo💉💊 ▪️Median survival 7m NEC ▫️Immediate progression 41% NEC ▪️G3-NET do better, esp Ki67 <55% ⚠️Caution! NEC aggressive - need better systemic Rx 🔗 nature.com/articles/s4141…

Home for AQC Chirurgie Québec ⚜️ to talk ergonomics & teams💙 Nothing beats being back where & with those thanks to whom I became a surgeon 😷 Unique place where tough topics can be tackled with an engaged, dynamic & fun group! Merci de l’invitation Jean-Pierre Gagné & toute l’équipe!🙏🏻

Stable OR teams contribute to better outcomes🤝✨ Each additional case done by same anesthesiologist-surgeon team 👉 ⬇️ major morbidity 🔓‼Opportunity is knocking: ⬆️outcomes by re-organizing teams How to do it? 🆕📝JAMA Surgery tinyurl.com/yx44pm96

On the importance of familiar and stable teams in the OR to optimize patient outcomes 🤔Why? 🧐How? 🤨What to do next? 🎧in JAMA Surgery podcast! tinyurl.com/3pkant4u So much fun chatting about it with Amalia Cochran 🎙️- thanks for the opportunity!

Designing stable high-functioning teams may not be as sexy as 🤖 or new technology But it can ⬆️ outcomes & is cost neutral Healthcare is one of the only fields where we expect teams that don’t know each other to perform at their best in high-stake situations. Why not change?

Breaking News! (Quite literally 😍) #ASCO25 🚨 BREAKWATER trial (NEJM): EC + mFOLFOX6 sets new 1L standard in BRAF V600E-mutant mCRC ➡️OS: 30.3 vs 15.1 mo (HR 0.49, P<0.001) ➡️PFS: 12.8 vs 7.1 mo (HR 0.53, P<0.001) ⚠️ Grade ≥3 AEs: 46.1% vs 38.9% — manageable, consistent with

2. #BREAKWATER: Ph 3, Enco + Cetux + mFOLFOX vs SoC in BRAFV600E mCRC - mPFS improved: 12.8 vs 7.1 mos (HR: 0.53) - mOS improved: 30.3 vs 15.1 mos (HR: 0.49) - Gr≥3 AEs: 46.1% vs 38.9% - This is the new SoC for BRAFV600E. This was U.S. FDA approved in December 2024! 3/6

Not in Chicago but getting the updates - #ASCO25 learnings today: 😀there's an option in BRAFV600 mCRC 😀Ipi+Nivo better in MSI-h unresectable mCRC 🫤ctDNA+ still not guiding care in CC 😳CRS+HIPEC no better with chemo Oncology Brothers got the details x.com/OncBrothers/st…

More 💊💉 options coming for #NETs & NEC, from #ASCO25 BiTE in epNEC - Jaume Capdevila Phase 1 Good ORR (⤴️DLL3-h) 40% Alpha-RLT in NET - Thor Halfdanarson on Only 9 patients Good AE profile - no dose-limiting toxicity Response observed Keep👀 on the many ongoing trials!

Scandinavian 🇳🇴🇸🇪🇩🇰ASAC trial (RCT) results at #ASCO2025: 466 patients randomized post-surgery for colorectal cancer liver mets; Aspirin did not improve 3y DFS vs placebo. Conclusion: ASA should NOT be used in this setting. Oslounivsykehus Norges forskningsråd IHPBA E-AHPBA ASCO

Au-delà de la peine de perdre un ami, j’ai surtout de la peine pour le Québec qui perd un allié de la qualité des soins. À une époque où tout est blanc ou noir, Serge était capable d’analyse, de sensibilité et de compromis. Il va nous manquer. 🥺

Sub-typing to select NAT in #PDAC? NeoPancONE 🇨🇦 #ASCO25 Canadian Hepato-Pancreato-Biliary Association 👥84 resectable PDAC 💉mFOLFIRINOX NAT Median OS 34 months😀 🔬Classical vs basal sub-type main predictor EFS & OS What next🤔: sub-type all PDAC prior to chemo? wait for more data? ascopubs.org/doi/10.1200/JC…

Most viewed this week from JAMA Surgery: Increasing the familiarity of surgeon-anesthesiologist dyads represents an opportunity to improve patient outcomes for GI, gynecology oncology, and spine surgery. ja.ma/3ZSw51n

Congrats Lev Bubis on this NET research grant! 🎉👏🏻 Great work to define priorities in NET surgical care research with CUTNETs Group Thanks CNETS for supporting early career investigators in NETs research 🙏🏻🦓