ACE2-independent SARS-CoV-2 infection! A new study shows that #TMEM106B, a lysosomal transmembrane protein, can serve as an alternative receptor for SARS2 entry into ACE2-negative cells. Spike mute E484D increased TMEM106B binding, thereby enhancing TMEM106B-mediated entry 1/

Three new preprints on TDP-43 and alternative polyadenylation, each identifying new target genes: biorxiv.org/content/10.110… (Fratta lab) biorxiv.org/content/10.110… (La Spada lab) biorxiv.org/content/10.110… (Gitler lab)

Shahar Sukenik I just read a paper where the authors show how structural biases in IDP ensembles found in vitro are recapitulated inside human-derived cells, you should check it out Shahar Sukenik ! nature.com/articles/s4159…

Study identifies a fluid biomarker of TDP-43 dysfunction, a central pathological feature of the #ALS-FTD disease spectrum, and demonstrates that such loss of TDP-43 splicing repression occurs presymptomatically Johns Hopkins Pathology, Hopkins Neuroscience Katherine Irwin nature.com/articles/s4159…

Researchers say they have uncovered more evidence to support a controversial hypothesis that sticky proteins that are a signature of Alzheimer’s disease can be ‘transmitted’ from person to person through certain surgical procedures go.nature.com/48OqwUr

Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection | Science Advances science.org/doi/10.1126/sc…

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes: cell.com/neuron/fulltex…

What makes a specific #protein to #misfold into irreversible vs reversible #amyloids? This question has long remained unanswered, but not any longer. Wanna know more? Please read our latest publication Nature Communications rdcu.be/dVyit Great collaboration with Jiangtao Zhou

Twenty years of Addgene As the non-profit plasmid repository celebrates two decades, Nature looks at the stories behind some of its most requested DNA tools. go.nature.com/3XKVsAn

Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines: nature.com/articles/s4159…

Genes whose evolution helped make us human may make us vulnerable to frontotemporal dementia. UC San Francisco ow.ly/VFRq50TJWFO

The Union Cabinet, chaired by Prime Minister Shri Narendra Modi, has approved One Nation One Subscription, a new Central Sector Scheme for providing country-wide access to scholarly research articles and journal publication. Steered by the Department of Higher Education and the

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: biorxiv.org/content/10.110…

We enjoyed a wonderful Christmas lunch together and wish you a Merry Christmas and a Happy New Year 2025, filled with exciting discoveries!

This review focuses on the importance of disordered water molecules in protein structures and discusses currently established methods of measuring the hydration states of proteins, their applications, and limitations. ow.ly/wknc50UtrIN

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress: nature.com/articles/s4159…

Molecular Stress in Old Neurons Increases Susceptibility to Neurodegenerative Diseases, Study Finds today.ucsd.edu/story/molecula…

Probing condensate microenvironments with a micropeptide killswitch: nature.com/articles/s4158…

Whether by soccer or American football, repeated blows to the head knock out neurons nestled within the folds of the brain, and strain cognition. Boston University Columbia University ow.ly/keEm50X3zaF