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Protein engineers and biochemists (and everyone, really), check out this awesome work by Kadina Johnston constructing a 160,000-member fitness landscape in the active site of (my favorite enzyme!) TrpB. There's one neat result (among many) that I wanted to discuss in more detail: (1/9)

Recently out at Nat Chem Bio! I used my Ras biosensors (Zhang et al Nat Biotech 2024) to profile the activity and environment of Ras at the single-cell level, which unveiled the signaling mechanisms underlying RasG12C inhibitor resistance. nature.com/articles/s4158… Institute for Protein Design

This a a great opportunity to work for an amazing mentor :)

🧬How do transcriptional cofactors recognize which genes to regulate?🧬 Check out our new preprint from Polly Fordyce Bintu Lab that tackles this question and provides the first-ever quantitative map of disordered transcriptional protein interactions (1/9) biorxiv.org/content/10.110…

This collaboration with Polly Fordyce driven by Nicole DelRosso and Peter Suzuki is a dream come true: we know hundreds of activators sequences, but how do they work? We can now measure protein-protein interactions at scale in vitro and connect them with expression in cells!

The final protocol for unbiased binding of small molecules to rna in cells and in vitro is now Publish here - star-protocols.cell.com/protocols/3679 hope it is useful

Check out this position! A great opportunity to do cutting-edge collaborative work in a really amazing environment.

Congratulations to postdoc Karl Krauth for being awarded a Branco Weiss fellowship! Thrilled that this computer scientist dared to learn to do experiments and excited to see what we can learn about protein sequence/function relationships! brancoweissfellowship.org/fellow/krauth/