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Make publication ready figures from your #AlphaFold PAE files. Works on multimer and AlphaFold 3 files. Customize colors and export as an SVG for editing in illustrator! thecodingbiologist.com/tools/pae.html

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. Max Planck Institute of Biochemistry (MPIB) 👇👇👇

Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, Jenny Sachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵

The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work @PauliGroup Cell Press reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB European Research Council (ERC)

#SSP2024 is almost here! Last thing to do is stapling together programs ⁦Broad Institute⁩ with ⁦Francis O'Reilly⁩ and ⁦Malvina P⁩! See all 235 of you tomorrow! #TeamMassSpec #proteomics

Nevan Krogan Krogan Lab Gladstone Institutes UC San Francisco keynotes the first day of SSP 2024 with a manifesto on the universality of PPIs in human disease. “Every protein is important. And every protein is connected.” #TeamMassSpec #Proteomics

.Fan Liu lab Max Ruwolt Diogo Borges @milanzord @absea_bio @Julia_RtaAn introduce a XL-MS standard based on human proteins or protein fragments produced in E. coli. The paper also introduces Scout, a search engine for XL-MS studies with cleavable cross-linkers. nature.com/articles/s4159…

Truly honored that our work was highlighted as one of many applications where #Alphafold has had an enormous impact. As someone who quickly became obsessed with Alphafold during the early days, it’s particularly special to get recognized by scientists whom I greatly admire.

Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.

I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….

🚨Preprint, RT appreciated🙏 Our work ‘Substrate recognition by human separase’ by jun, Sophia Schmidt, Margherita Botto UNIGE_en Université de Genève Molecular & Cellular Biology Dept 🔬 Geneva 🇨🇭 Dubochet Center for Imaging (DCI) and members from the Morgan UC San Francisco and Francis O'Reilly labs is online. 🔗biorxiv.org/content/10.110…

Excited to share some work in our collaboration between Stephen Fried JHU and Ed O'Brien Penn State Chemistry, just published in Science Advances : science.org/doi/10.1126/sc…. Here we describe the structural basis for stretched exponential kinetics in protein folding. A thread.

we are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system. However, there is freedom to shape projects in own ways.

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: biorxiv.org/content/10.110… This work spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

Ever wondered how several individual RBPs cooperate to repress translation? To figure it out, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! Lead by Marco Payr 🇺🇦 and great collaboration with Hennig lab! biorxiv.org/content/10.110…

Excited to share our new Science Magazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. science.org/doi/10.1126/sc…

Despite the chaos and turmoil, our lab is blessed to have 3 new postdoctoral fellow openings and we would welcome scientists interested in: - combining single-molecule studies with cryo-EM - developing new protein design tools using bioinformatics and structure-based tools -

RIP Brian Wilson. Sharing BBC Music’s tribute to The Beach Boys “God Only Knows”