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Hey #arvo2022! Come check out my poster (F0408) on human RPE heterogeneity. We defined 5 RPE subpopulations with different sensitivity to retinal diseases. Thanks to BrightFocus Foundation and all the colleagues in Kapil Bharti lab for contributing to the work!!

Finally out in PNASNews!! Thank you to Ruchi Sharma and Kapil Bharti that made this work possible and all the people that contributed to the work! NEI

This paper came out while preparing for another paper, and that is the beauty of science! please check this paper out Davide Ortolan has done an amazing job! We all are so happy working with Kapil Bharti! Stay tuned, a lot more to come from our lab!

Ruchi Sharma (Ruchi Sharma) and I will host an ARVO virtual Special Interest Group on Thursday about correlating genotypes to phenotypes in culture models of macular disease with Aparna Lakkaraju (UCSF), Ruchira Singh (Rochester), and Jennifer Chao (U. Washington).

Please attend!! We have put together a plan with a fantastic line of speakers! We hope to see you there and have a great discussion on cell culture modeling for mono and polygenic retinal disease. Thursday, May 12, 10:00-11:30 am EST. Go

Congratulations to NEI Intramural researcher Mitra Farnoodian Tedrick (from @BhartiLab) for receiving the Knights Templar Eye Foundation grant to help develop potential therapies for #Stargardt disease! bit.ly/3NKQXyM

It's is a once-in-a-lifetime moment, and I am lucky to live this! Davide Ortolan Kapil Bharti Mit Far Shekhar Jha francesca barone Dominik Reichert NEI

What a achievement! Excellent team work and commitment to bring the product to the clinic! Ruchi Sharma Kapil Bharti Davide Ortolan francesca barone @ thank you NEI for the support!

Glad to be the part of this journey with Mit Far Shekhar Jha francesca barone Davide Ortolan and many twitterless colleagues Arvydas Maminishkis, Irina Bunea, Juan Amaral, Roba, Sarmila,Jeff, Fang and many more.

Our lab's ⁦Kapil Bharti⁩ first Stargardt In-vitro disease modeling paper is out today! ⁦Mit Far⁩ showed patient iRPE recapitulates disease phenotype. Congratulations, Mitra! ⁦Check it out to find more details! cell.com/stem-cell-repo…

Ruchi Sharma Mit Far Our lab breaks down another dogma - ABCA4, whose mutations lead to Stargardt disease, is only important in retinal photoreceptors. Our lab shows ABCA4 is also important in the retinal pigment epithelium. New insights for gene therapy. Outstanding work Mit Far NEI

Davide Ortolan follow-up paper on the detailed protocol of human RPE/choroid generation is out in JOVE! I am sure you all will want to read it! Check the link! review.jove.com/t/64761/effici… Kapil Bharti

Researchers from NEI's intramural program developed a new stem cell-based model of Stargardt disease. First direct evidence that Stargardt-related ABCA4 gene mutations affect RPE. IOVS Journal paper: bit.ly/3UaB1tw Mit Far @BhartiLab

What a pleasant surprise seeing our 3D printed eye tissue selected as the #ImageOfTheMonth. Thanks NEI. Great work team!

1/2 Brian Brooks (NEI) studies ocular development and coloboma (cause of childhood blindness). Beautiful work: critical role of ZFP503 gene in RPE differentiation & optic fissure closure. IOVS Journal: bit.ly/3U5CrWd Dr. Sara Thomasy (she/hers) Gavin Arno Andrew Lotery

So excited to share our recent Nature Methods manuscript with 3D-printed models of #AMD and the eye. This is what I call a disruptive technology. What an awesome job by our team NEI and NCATS

Congratulations Kapil Bharti It's a proud moment for all of us! We all be rooting for your success in this new journey!

Dr. Kapil Bharti is the new scientific director of the NEI Intramural Research Program. He’s led our Ocular Stem Cell and Translational Research Section since 2012. Join us in celebrating Dr. Bharti’s new role! Read more: nei.nih.gov/about/news-and… #NEIResearchNews

This works validates a study we published in 2021 about an in vitro #AMD model that recapitulates key cellular features of RPE pathology. Observations in a mouse model were reproduced in patient stem cell derived RPE in a masked study. Great work team! Ruchi Sharma #ipscs

We are proud that the NEI's Diversity In Vision Research and Ophthalmology (DIVRO) summer internship program has been a key stepping stone for many trainees. Great story about one participant: Luke Nelson (Howard University Columbia University) bit.ly/4drG5TJ