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All Americans should be horrified and outraged by the brazen terrorist attacks on Israel and the slaughter of innocent civilians. We grieve for those who died, pray for the safe return of those who’ve been held hostage, and stand squarely alongside our ally, Israel, as it

Now online! Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals dlvr.it/SzP6pT

New issue online! In honor of the #NobelPrize2023 awarded to Katalin Kariko & The Drew Weissman Lab, an essay from Brian Brown, Anthony Fauci, Belkaid Lab & Miriam Merad, MD, PhD tells the story of their transformative discovery: the successes and challenges, and the perseverance and vision that were

Excited by our study Immunity showing that senescent monocyte-derived macs (driven by MAPK mutations) which we showed lead to macs prolonged survival and cytokine release breakdown the BBB, infiltrate the brain and promote neurodegeneration sciencedirect.com/science/articl…

Kiianitsa, Lukes et al. show that multiple Alzheimer's disease-associated TREM2 variants exert their pathogenic effects via altered TREM2 splicing. tinyurl.com/3hecu5yj

A micrograph of some groups of neurons from the lateral geniculate nucleus (LGN), one of the regions in the brain responsible for visual processing! The neurons in the photo are known as magnocellular cells (🟠) and are surrounded by astrocytes (🔵) and other cellular types.

Mount Sinai researchers have shown for the first time that immune cells called monocytes can be drawn during stress into sites in the brain that control emotional behaviors. These data establish a novel mechanism by which the immune system can affect central nervous system

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models biorxiv.org/content/10.110…

Excited to share the latest story from our group in Cell and so proud of the great science and incredible dedication of first authors Leah Dorman and Caroline Escoubas Güney and all co authors (more details to follow) sciencedirect.com/science/articl…

Congratulations to Hong-Gyun Lee for his study out today in nature! We describe epigenetic memory in ACLY+p300+ astrocytes that worsens MS pathology nature.com/articles/s4158…

Trying this again: I’m a terrible PI for not posting this sooner. A recent review published from my lab UMass Chan Department of Neurobiology UMass Chan Medical School from the fabulous Violeta Durán on activity-dependent regulation of microglia within neural circuits: nyaspubs.onlinelibrary.wiley.com/doi/10.1111/ny…

Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders nature.com/articles/s4159…

cell.com/trends/immunol… thanks to Prof. Akiko Iwasaki for this lovely spotlight of our work on Type I interferons in brain development, including implications for future studies of how viruses may impact the brain.

Microglia can make their own pathogenic tau, wrecking phagocytosis TREM2 signaling, and spewing a brew of neurotoxic molecules. @WUSTL ow.ly/Mv4850ScjyQ

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related neurodegenerative leukoencephalopathy: Neuron cell.com/neuron/fulltex…

Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes Immunity cell.com/immunity/fullt…

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According to dynamical systems, psychiatric disorders can be seen as energy landscapes with peaks and valleys. OCD has deep valleys where neural activity gets stuck, while schizophrenia has shallow valleys that let neural activity roam too freely, connecting unrelated ideas.

Thrilled to share our latest work on how #SHIP1, a gene linked to #neurodegeneration, affects #microglia in early #brain development. Congrats to Alessandro Matera, Compagnion Anne-Claire and the many #collaborators Immunity Faculté de biologie et de médecine (inactif) sciencedirect.com/science/articl…

Online now: The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance dlvr.it/TGqBy3