Albumin, 10 myths 1️⃣leaks into interstitium 2️⃣ ⬇️volume expansion vs artificial colloids 3️⃣ ⬇️AKI 4️⃣ sepsis: ⬆️survival 5️⃣ ⬆️diuretics effects 6️⃣RRT: ⬆️ fluid removal 7️⃣cirrhosis: ⬇️mortality 8️⃣TBI: ⬆️mortality 9️⃣correcting hypoalb ⬇️mortality 🔟 ⬆️NaCl 📎 bit.ly/3KkeAwK

1/🧵Vitamin C doesn’t work for #Sepsis, and we now know that for sure. Here’s a back story to one of the largest trial that proved the truth: VICTAS One day I was sitting at my desk and a guy from Facebook called to offer us millions of 💰 💰 💰… bit.ly/358Dj8w

Today we share our (Amol Verma & Fahad Razak) COVID-PRONE RCT The BMJ. We found that patients had a hard time prone positioning for prolonged periods. And prone positioning did not seem to improve outcomes. Our trial was stopped for futility. bmj.com/content/376/bm… 1/5

In this trial of IV vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. #CCR22 nej.md/3HpUNvW

1/2 Great talk Matthew Jefkins! Key points: -prognostication after TBI is hard -don't use prognostic calculators (eg CRASH, Impact) for individual prognosis -most recovery occurs between 3-6 months, but some patients can go from "dependent" to "independent from 6-18 months

When it’s time to discharge a patient from the ICU, is it ever safe to send them straight home? Eric Sy & researchers Sehar Parvez & Dr. Ryan Donnelly say yes, it can be. Hear why, on Researchers Under the Scope ow.ly/4NN250N9WgB U of S CoM Office of the Vice-Dean Research @USaskEM Critical Care Medicine

What are the outcomes after critical illness? Great review by Dr. Herridge and Elie Azoulay published on NEJM Provide a patient and caregiver perspective, during and after ICU Everyone caring for critically ill patients should read this 🔗 nejm.org/doi/full/10.10… #FOAMcc

In my 10+ years of co-survivorship, doing life with Dr. Glaucomflecken through 2 separate cancers, 1 SCA and fighting off his death with 10 mins of #CPR, only ONE (1) of the medical professionals we interacted with has ever asked how I was doing. Meet Roger. authors.elsevier.com/a/1giY02p-l5Vhe

This work takes a big team. Recognizing also our Saskatchewan co-investigators and funders Saskatchewan Health Research Foundation - SHRF PharmaStache Sandy Kassir

Management of severe community-acquired pneumonia: ERS ESICM ESCMID ALAT international guidelines ➡️ evidence-based recommendations for diagnosis, empirical treatment, ABTs ➡️ current knowledge gaps ➡️ recommendations for future research 🖇️ bit.ly/3m4tC3n

Key point to highlight: rapid reduction in PaCO2 is associated with increased stroke risk. This is a major *modifiable* risk factor, and one that everyone who is involved in ECMO needs to be aware of.

Proton pump inhibitors in older adults: Potentially inappropriate use of PPI, new PPI prescriptions and PPI deprescribing were frequent among older adults with multimorbidity and polypharmacy in the OPERAM trial ➡️ cmajopen.ca/lookup/doi/10.…

“Standing on the edge of death now, I feel compelled,” writes Amy Silverstein (Amy Silverstein, author), “to use my experience in the transplant trenches to illuminate and challenge the status quo.” nyti.ms/3A5qIi2

New SCCM guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU. They are focusing on infectious disease, peri-transplant, gastrointestinal, and neurologic issues

Return to Driving After Critical Illness bit.ly/3UAK0Wj #icurehab #A2Fbundle