Twitter Beğeni Hilesi

Interesting study on the more efficient generation of ETX embryoids by genetically inducing Fgfr2 along with Gata6 to speed up PrE identity reinforcement.

Using the spliceosome and splicing inhibitor Pladienolide B to form blastomere-like cells that efficiently form blastoids, albeit with low number of PrE cells: pubmed.ncbi.nlm.nih.gov/36633710/

Happy to share our detailed protocol for the generation of human blastoids modeling blastocyst-stage embryos and implantation, now out in Nature Protocols rdcu.be/c5HA1 Nicolas Rivron lab IMBA Vienna BioCenter [1/12]

Mouse trophectoderm stem cell (TSC) protocol paper from the Rivron lab. The combination of LPA, IL11, BMP7, Activin-A and 8Br-cAMP maintains the TSC stage more similar to the blastocyst trophectoderm. sciencedirect.com/science/articl…

Deciphering mouse placenta development: Single-cell transcriptomics reveals a differentiation roadmap of trophoblast cells from E7.5 to E14.5. nature.com/articles/s4142… #PlacentaDevelopment #SingleCellTranscriptomics"

Thank you so much, Angela. I hope only that the press will report it correctly as the paper is not out yet. Any these are not embryos but embryo models made from stem cells.

1/n New Hanna lab PREPRINT: "Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs" biorxiv.org/content/10.110…