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2 papers out in December! Crazy that this is the normal rate for some labs. Michaela's on SIRT6 and DNA damage repair in chondrocytes (Aging, PMID: 38078876); Matt's on the "MagnaSquish" to test cartilage recovery during cyclic loading (J Biomechanics, PMID: 38128469).

Thank Dr. Dong Wang for a wonderful talk! Dr. Gordnine from NIEHS will tell us more about mutagensis this week. Sign up and watch the replay at cancer.columbia.edu/research/progr…

nature.com/articles/s4301… very interesting work showing role of APOBEC3C and D in restarting stalled replication forks. Highlighting diversity of roles with the APOBEC3 family.

Thank Dr. Gordenine for a wonderful talk. This week Social DNAing will host three rising stars. Sign up and watch last week's replay at cancer.columbia.edu/research/progr…

Motif analysis in confluence with mutation signatures revealed new source of mutagenesis in humans cell.com/cancer-cell/fu…

Now online! APOBEC3A and APOBEC3B drive distinct mutational landscapes in tumors. We showed how A3A and A3B substrate preferences for different hairpin structures can be exploited to identify patients' tumors with mutations caused by either A3A or A3B. nature.com/articles/s4146…

#PLOSGenetics: Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells dx.plos.org/10.1371/journa… Kudos to Steve Roberts and co-authors. This is a good follow up to Steve's 2013 finding of more APOBEC mutagenesis in HER2-enriched BRCA

Amazing science and traditional hike at FASEB "Genetic Recombination and Genome Rearrangements 2024" conference in Tucson, AZ. Such a beautiful location!!!

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast academic.oup.com/g3journal/arti…

❓Want to learn an easy trick to improve your mutational signatures? ‼️Extract them from SNV and indel mutations jointly! A study by our Patricia F. Patricia Ferrer Torres now online, focusing on HR deficiency signature SBS3🧬 Here is a TL;DR for you 👇 (1/3)

📢 Calling all early-career researchers Do you want to: 🟠 develop your research identity 🟠 work on groundbreaking projects 🟠 gain leadership skills? Our Early-Career Award is for you. Apply by 25 Feb 2025 ➡️ wellcome.org/grant-funding/…

The National Institutes of Health (NIH) has created a wealth of data management, sharing, and artificial intelligence resources for researchers at NIEHS and other institutes. bit.ly/3OJNtQb #NIEHSFactor

“Paris declaration to spearhead fight against fake science.” researchinformation.info/news/paris-dec…

Since coming to Congress, I have made it my mission to advocate for stronger food safety measures, greater transparency, and proactive solutions to protect public health. Prevention starts with knowledge, which is why I l launched The Wellness Watch—a new series designed to help

Changes in metabolic landscapes shape divergent but distinct mutational signatures and cytotoxic consequences of redox stress academic.oup.com/nar/article/51…

portlandpress.com/biochemsoctran… Excellent recent reviews covering mechanisms of repeat expansion.

Motif-Centered Analyses Elucidate Mutagenic Mechanisms Operating in Normal Human Tissues biorxiv.org/content/10.110… Identifying mutagenic mechanisms operating across human body