Obri et al from Detroit, Michigan, in an analysis of liver center registry data, reported that referral for end-of-life care in patients with advanced, terminal hepatocellular carcinoma were more common among Black than in white patients. bit.ly/3PRwiOg

Long-standing but not new-onset diabetes is associated with increased mortality among patients with pancreatic cancer. This information has implication for prognostication and risk stratification among pancreatic cancer patients. bit.ly/44jhoEg

The prevalence of esophageal inlet patch (IP), a finding of controversial consequence, was reported to be of higher among patients with Barrett’s esophagus (BE) along with pathophysiological similarities of IP and BE, suggesting shared etiology. bit.ly/3qXeJSW

Gastroparesis induced by atropine or dopamine worsened NSAID-induced gastric antral ulcer formation in refed mice via enhanced bile reflux via 5-HT3 and dopamine D2 receptors, with the possible involvement of increased duodenal motility. bit.ly/44WOF8q

In 1993, groundbreaking research in DDS unveiled the impact of GLP-1 on human GI functions, redefining our understanding of gastric emptying and more. bit.ly/3ZfeAXJ

Fast forward to 2022, Jens Holst reflects on his pioneering discovery in a fascinating perspective piece. bit.ly/46909GG

↑ inpatient mortality during all COVID-19 variants except Omicron vs pre-COVID 1.2 ↑ odds of 30-day readmission pre-vaccination vs. pre-COVID Check out the full article in Digestive Diseases and Sciences by Patrick Twohig et al here: bit.ly/3Sr3wW1

Dang et al from Vietnam and Australia conducted a retrospective study of subjected aged 18-50 with advanced polyps or colorectal cancer, finding that that siblings of the same age group had a much higher risk of colorectal cancer than did matched controls. bit.ly/4eNqWhH

Culpepper et al tested the effect the probiotic yeast S. boulardii engineered to adhere to fibronectin and release TNF nanobodies on colonic inflammation and tumor burden in mice. The native and engineered yeast both reduced inflammation and tumor burden. bit.ly/3JmOZs6

Alsakarneh et al retrospectively studied the response of patients with pouchitis and resulting from IBD surgery, finding that treatment with bile acid sequestrants was noninferior or possibly superior to the current standard, antibiotic treatment. bit.ly/4mUEVoz

Mishra et al studied 100 patients who underwent EUS/FNA for pancreatic cysts, reporting a diagnostic accuracy of > 90% for most cases with a consequent reduction in the need for surveillance in those with benign lesions. bit.ly/4fNyelM

What are predictors for achieving textbook outcomes after endoscopic resection of GIANT submucosal tumors in esophagus and cardia? link.springer.com/article/10.100…

Image of Month: Gastric #cancer metastasis mimicking rectal #IBD This case reminds us to be vigilant about malignancy in IBD. link.springer.com/article/10.100…

Meta-analysis: Interplay of immunity and gut microbes🦠in #IBS ⬆️Pro-inflammatory cytokines (TNF, IL-6) ⬇️Anti-inflammatory cytokines (IL-10) ⬆️Bacteroidetes ⬇️Firmicutes link.springer.com/article/10.100…

#MELD-Na vs. MELD3.0 ➡️ consistent discrimination across major ethnic/racial groups ⚠️ at higher values, both can overestimate outcomes 🗒️ some site-specific differences exist 🔗link.springer.com/article/10.100…

Is #IBD a risk factor for perforation during #colonoscopy? Systematic review/meta-analysis 🙂Good news. Short answer is no. 🤔Possible risk factors to consider: disease severity, corticosteroid use 🔗link.springer.com/article/10.100…

🎖️Editor's Choice: Ramai et al. from Boston and Saudi Arabia retrospectively analyzed 763 patients who underwent ESD 🔑prior manipulation (e.g., EMR, tattoo) or submucosal fibrosis = ⬇️lower success of subsequent ESD 🔗link.springer.com/article/10.100…

#Colonoscopy for heart 🫀transplant candidacy: 👉LVEF <30% (n=231) 🆚 >30% (n=91) ⏺️Retrospective, single center ⏺️Bowel prep and scope in a monitored, inpatient setting 🔑Similar AEs and no SAEs 🔑Similar ADR 🔗link.springer.com/article/10.100…

NASHFit RCT 🤼moderate aerobic exercise training vs. SOC ➡️20 wks: ↑ MASH resolution (33% vs. 13%) 🔗link.springer.com/article/10.100…

🎖️Editor's Choice: John Damianos, M.D. et al. from Mayo Clinic reported on 24 patients with Yao syndrome ➡️100% had GI symptoms (esp constipation and bloating) ➡️all tested having dyssynergic defecation link.springer.com/article/10.100…