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🧬New paper + tool out of Patrick Hsu @skonermann Labs, led by @StanfordBioE Ph.D. student Jingyi Wei: a new RNA targeting CRISPR enzyme paired with a convolutional neural network (CNN) model predicting highly efficient guide RNA sequences for transcriptome engineering.

High-throughput PRIME-editing screens identify functional DNA variants in the human genome dlvr.it/T0YQyc

Would CRISPR screening help you discover new biology? Check out our methods primer for a hands-on guide (nature.com/articles/s4358…), co-authored by many experts in the field. Published in 2022, this review has already >150,000 views/downloads (according to the journal). Thank you!

In some new work (the first from the new lab!), we lay out a vision for a biological foundation model that unites DNA, RNA, and protein modalities and operates at molecular, systems, and genome levels of scale. Blog: arcinstitute.org/news/blog/evo Preprint: arcinstitute.org/manuscripts/Evo

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments biorxiv.org/content/10.110…

如何使用 ChatGPT 原理学会一切知识？读Wolfram 大神的神书《这就是 ChatGPT》之后的读书笔记 读了李沐大神的《使用随机梯度下降来优化人生》，忍不住拍大腿。加上前面推荐了wolfram 大神的神书《这就是 ChatGPT》，于是觉得有必要写点类似读书笔记或书评的东西。李沐的文章写于ChatGPT

My 8-year old son's drawing on Eurocup #EURO2024

I'm thrilled to share my lab's first manuscript identifying that paraspeckle protein NONO regulates active chromatin through allosteric activation of NSD1 on BioRxiv: biorxiv.org/content/10.110… As a baby PI who started in a literally empty building, we weren't able to do biochem

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Today Arc Institute releases State, our first perturbation prediction AI model and an important step towards our goal of a virtual cell State is designed to learn how to shift cells between states (e.g. “diseased” to “healthy”) using drugs, cytokines, or genetic perturbations

I am thrilled to join UMSOM and work with many great scientists here!

Our Cell paper is online (doi.org/10.1016/j.cell…)! We present the CIDE framework, broadly applicable to cancer research and oncology. Also, we highlight AOAH as a promising new immunotherapy.

Application is still open until Aug 25. Great for trainees of all levels. Come and join us!

Following 2023 paper, our new study on TE regulation is out today Nature Cell Biology! nature.com/articles/s4155…

🧬 Building the Virtual Cell starts with data. Today, we’re making the X-Atlas/Orion Perturb-seq dataset even more accessible — now live on Hugging Face Hugging Face 🤗 📊 One of the largest & highest-quality perturbation datasets ever released, it provides the foundation for