[Publication Sharing]⏰ --Chemical proteomic discovery of isotype-selective covalent inhibitors of the RNA Methyltransferase NSUN2. In this paper, the authors employed Activity-Based Protein Profiling (ABPP) to identify covalent inhibitors that selectively target human NSUN2.

Abnormalities in Post-translational Modifications (PTMs) have been extensively linked to metabolic diseases. A review in Signal Transduction and Targeted Therapy (IF=39.3) explores PTMs' roles in diverse metabolic disease processes, mechanisms, and the latest advancements.

🚀Science Update: Recently, researchers introduced a #chemoproteomic method to precisely map the binding sites of photocrosslinking probes in #cells, addressing the challenge of identifying exact crosslinking sites between small molecules and #proteins. doi.org/10.1038/s41589…

Glad to share our work on profiling metalloproteomes by thermal proteome profiling and many potential metalloprotein candidates discovered rdcu.be/dzDGq

Transforming non-covalent interactions between small molecules and protein targets into covalent bonds with our innovative in situ photo-crosslinking technique! This allows direct capture of active molecule targets from proteomes, shedding new light on their MOA. #Protein💡🔬

A new method directly captures substrates of lysine-modifying enzymes in live cells using residue crosslinking, enhancing understanding of PTM-enzyme interactions and substrate profiles for various bacterial and mammalian enzymes. #protein #ptm DOI: 10.1038/s41467-024-45765-3

Today is #InternationalRareDiseaseDay. Let's stand together for the millions living with rare diseases, advocating for better diagnosis and access to treatment. Every patient matters, every disease counts. #RareButNotAlone 💚🌍

💥🔬Researchers from Peking U led by Wang Chu & Xiao Junyu introduce METAL-TPP, a game-changer in metal-protein interaction studies. This novel method uses thermal stability to dissect metal effects on proteins, driving advances in #Metalloproteomics. doi.org/10.1038/s41589…

🎯📊A single chart illustrates the advantages of chemical proteomics in lead compound discovery. #ChemicalProteomics #LeadDiscovery #ABPP #DrugDev

🧐Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.🧪 Read on: pubs.acs.org/doi/10.1021/ac…

🚀 Elevate bio-research with Streptavidin Magnetic Beads! Capture target proteins swiftly, boost lab productivity. Must-have for every lab: Streptavidin Magnetic Beads 💪 #StreptavidinBeads #BioResearchTools 🧬

✔️Let a table illustrate the advantages of chemical proteomics over structural biology techniques in elucidating the binding modes between drugs and target proteins. #ChemicalProteomics #DrugDiscovery

ChomiX chemoproteomics platform excels in discovering protein targets for natural products in Chinese medicine. #Chemoproteomics #NaturalProducts #ChineseMedicine

Identified Withangulatin A (WA) via chemical proteomics as a natural compound capable of covalently inhibiting PHGDH, a key enzyme in serine metabolism linked to cancer. This discovery offers potential avenues for novel cancer therapies. #ChemProteomics #CancerResearch

ChomiX's chemoproteomics platform for profiling of protein targets for noncovalent small molecule drugs. The platform's range includes bioactive small molecule drugs such as endogenous metabolites, natural products, and synthetic molecules. #DrugDevelopment #Chemoproteomics💊🔬🧬

Differential proteomics 🔬 investigates proteome changes under different conditions, identifying key markers for analysis. Using the ChomiX protocol, thousands of proteins can be quantitatively identified. #Proteomics #Research 🧬💼

Associate Prof. Zhifeng Du's team at Huazhong University of Science and Technology teams up with Chomix for a groundbreaking study on cisplatin's protein targets using chemical proteomics. Deepening our understanding of anticancer mechanisms. #CancerResearch #Proteomics 🧪🔬👩‍🔬

Associate Prof. Zhifeng Du's team at Huazhong University of Science and Technology teams up with Chomix for a groundbreaking study on cisplatin's protein targets using chemical proteomics. Deepening our understanding of anticancer mechanisms. #CancerResearch #Proteomics 🧪🔬👩‍🔬

Breaking through inflammation barriers with chemical proteomics: Exciting progress in anti-inflammatory research targeting SLC15A4 with novel inhibitor AJ2-30. (IF 14.8) #Proteomics #InflammationResearch🧪🔬🌟 Read on: nature.com/articles/s4158…

So excited to see two Nature articles about the discovery of WRN inhibitors, nature.com/articles/s4158… especially covalent allosteric inhibitors discovered by the chemical proteomics platform. nature.com/articles/s4158… Chemical proteomics👏👏👏