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HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics - now out NatureStructMolBiol - free link rdcu.be/dE0wf Yining Jiang Boudker Lab Molecular Biophysics Training Program WCM Office of the Research Dean Weill Cornell Medicine Anesthesiology Conformational landscape of a single molecule

Thrilled to announce our latest work in NatureStructMolBiol on HS-AFM single-molecule structural biology with Scheuring Lab ! Marching towards our long-standing goal, we've directly linked the conformations of a single molecule to its instantaneous activity... nature.com/articles/s4159…

Got an asymmetric ion channel that needs characterising? Then check out David Seiferth's PoreAnalyser extension of HOLE available as a pip-installable package: github.com/bigginlab/Pore… online here: poreanalyser.bioch.ox.ac.uk Preprint: biorxiv.org/cgi/content/sh… Department of Biochemistry at Oxford University

Sangyun Lee accardilab Boudker Lab Robertson Laboratory @ WUSTL reveal the mechanism by which protons gate a CLC-type Cl-/H+ exchanger nature.com/articles/s4159…

Looks very interesting! Thanks Phil Biggin 🇪🇺 Do you think it can be applied to oddly shaped pores, such as the lipid grooves of scramblases or the tortuous pathways of CLCs? Traditional HOLE has a hard time, especially with scramblases, which are partially open to the membrane

Excited to share our recent study Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 published this week nature led by amazing Yeeun Son in collaboration with Tim Kenny Artem Khan Kivanc Birsoy Memorial Sloan Kettering Cancer Center nature.com/articles/s4158…

🚨Want to learn more about the amazing work of our ⭐️2024 SGP #CranefieldAwards⭐️ recipients F Moussavi-Harami, MD, Teresa Crespo, and Shuya Ishii published in JGenPhysiol? 👏Join us online on🗓️ Wednesday, 15 May, at ⏲️ 12:00 pm Eastern! Register🆓👉bit.ly/sgp2024cranefi….

Excited to share a new direction on epigenetics & brain! science.org/doi/10.1126/sc… We made a mouse model for rare disease histone lysine acetyltransferase KAT6A Syndrome, & found its deficiency impairs cognitive functions by inhibiting WNT signaling in CA3 neurons KAT6 Foundation

@Nozomi_Ando’s research dives into the world of protein dynamics, aiming to elucidate protein function under allosteric interaction during catalysis & regulation. Listen to her Cohn Award lecture, "The structural biology of enzymes in motion." soundcloud.com/asbmb/nozomi-a… #DiscoverBMB

Don’t miss this!

Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript.. Structural basis for hyperpolarization-dependent opening of human HCN1 channel disq.us/t/4p78xec

🚨Abstracts deadline is 1 week away: 1 August! Submit at sgp2024.com for🧳Travel Award and💬Short Talk consideration! The #sgp2024meeting will focus on cutting-edge research on the functional conservation and molecular evolution of membrane-related molecules, such as

Thank you Crina Nimigean for involving us in this exciting project! Was a lot of fun to work with everyone on the teams!

Congrats Lisandra Flores-Aldama 🇨🇺 🇨🇱 🇺🇸 #patriayvida !! Well deserved award!

Postdoctoral position in computational biophysics, machine learning, and structural biology is open! Please see details in the attached.

New insights into the activation and internalization of glutamate receptor mGluR from Levitz lab, now in Nature Communications The "rolling TMD interface" model is based on electrophysiology, cell imaging, FRET and cryoEM doi.org/10.1038/s41467… 🦸Alexa Strauss Alberto Gonzalez-Hernandez Joon Lee

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a team led by Dr. Crina Nimigean and Dr. Elizabeth Kim of Weill Cornell Medicine Anesthesiology. Full story: bit.ly/4dmJrIh

Congratulazioni Francesca!

ninds.nih.gov/funding/about-… #NINDS Congratulations Sasha! Alexander Sobolevsky What a great honor!

Congratulations Sasha!