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Excited to share this preprint exploring potentially novel functions of nuclear tau in heterochromatin organization. Thanks to the hard work of Lannah Abasi, Nesreen, Manasi Movva and collaborators in Kevin Corbett lab BPS IDP Subgroup FragileNucleosome biorxiv.org/content/10.110…

Why do phages encode tRNAs? It aids in defeating tRNA-targeting immune systems. We provide structure and mechanism for the PARIS defense and show how it cleaves host tRNA upon trigger sensing. Stikingly, the non-cleavable tRNA of T5 supports the infection. biorxiv.org/content/10.110…

Ringing in the new year with a pre-print on the PARIS defense system! This work defines how viral proteins activate PARIS-mediated tRNA cleavage and how viral tRNAs rescue infection. tinyurl.com/5x7epzxd. Also check out complementary work from the Corbett lab!

Truly great work from Amar Deep on the structure and function of the PARIS defense system!

Also check out parallel work on PARIS from David Bikard , Artem Isaev, and Blake Weidenheft labs: biorxiv.org/content/10.110…

Association of the chromatin-binding domain of the yeast HORMA-domain protein Hop1 with bent nucleosomal DNA boosts meiotic recombination initiation in specific regions of the genome Andreas Hochwagen, Kevin Corbett and coworkers embopress.org/doi/full/10.10…

My second “first author” paper is published by Nucleic Acids Research! We show how one of the proteins I found from the proteomics screen (Enustun et al., Nat Struct Mol Biol, 2023) is important for mRNA transfer from the phage nucleus and for their translation.

Thrilled to share the final version of my postdoc project, out today in nature! We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism! More info in the thread below 👇 nature.com/articles/s4158…

If you're interested in learning even more about the Bil system, check out this amazing structural study by Lydia and Qiaozhen from Kevin Corbett's lab, which was also published in nature today! nature.com/articles/s4158…

Out today in nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett Kevin Corbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…

New in nature: Researchers Reveal the Molecular Mechanism Behind Virus Sensing and Infection Neutralization in Bacteria bit.ly/4dSeZWj 🧵

Excited to share our work in collaboration with Kevin Corbett on detecting protein-RNA interactions with RNA-base editing in situ in fixed cells and primary tissues. Congratulations Lisa Liang and Tao in our lab! Thank you Chan Zuckerberg Initiative for the support! nature.com/articles/s4146…

Had a blast working with Felix Randow on this commentary for the #ubiquitin-like anti-phage defense systems described recently by Jens Hör, Sorek Lab, Kevin Corbett, and teams. Give it a read! Ubiquitylation: Sword and shield in the bacterial arsenal authors.elsevier.com/c/1joCL3vVUPRm…